AccScience Publishing / GPD / Online First / DOI: 10.36922/gpd.4294
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ORIGINAL RESEARCH ARTICLE

Correlation between SIRT1 expression and overall survival across various cancers: A meta-analysis

Mehreen Iftikhar1† ,  Sana Tanveer1† ,  Samyyia Abrar2† ,  Amna Rehman3† ,  Shaaf Ahmad4 ,  Umair Ali Khan Saddozai5 ,  Faiqa Irshad1 ,  Kaleem Maqsood3 ,  Ali Afzal5,6* ,  Xin-Ying Ji7,8* ,  Muhammad Babar Khawar1,5*
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1 Department of Zoology, Applied Molecular Biology and Biomedicine Lab, Faculty of Sciences, University of Narowal, Narowal, Punjab, Pakistan
2 Department of Biological Sciences, Faculty of Allied Health Sciences, The Superior University, Lahore, Punjab, Pakistan
3 Institute of Zoology, University of the Punjab, Lahore, Punjab, Pakistan
4 King Edward Medical University, Lahore, Punjab, Pakistan
5 Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu, China
6 Molecular Medicine and Cancer Therapeutics Lab, Faculty of Sciences and Technology, University of Central Punjab, Lahore, Punjab, Pakistan
7 Faculty of Basic Medical Subjects, Shu-Qing Medical College of Zhengzhou, Zhengzhou, Henan, China
8 Department of Medicine, Huaxian County People’s Hospital, Huaxian, Henan, China
GPD, 4294 https://doi.org/10.36922/gpd.4294
Submitted: 21 July 2024 | Revised: 19 October 2024 | Accepted: 22 October 2024 | Published: 7 January 2025
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Sirtuin 1 (SIRT1) plays a complex role in cancer, significantly influencing cancer prognosis. However, its true impact remains unclear, necessitating a comprehensive and unified analysis. This study investigates the prognostic value of SIRT1 expression across different cancers worldwide. Relevant studies were retrieved from Google Scholar, PubMed, and Web of Science. Only human studies exploring the prognostic role of SIRT1 in various cancers were included in the study. Data on patient demographics, SIRT1 expression levels, and overall survival (OS) rates were extracted, followed by subsequent analyses, including meta-regression for heterogeneity and Egger’s regression for publication bias. A total of 15 studies (pooled hazard ratio = 1.483 ± 0.2974 [95% CI: 0.900 – 2.065]), predominantly from Asia (n = 10), were selected for the meta-analysis. The analysis demonstrated a robust and consistent association between elevated SIRT1 expression and poorer OS across diverse variables (P < 0.001), with minimal heterogeneity (I2 = 0.0001). Subgroup analyses confirmed significant effects of SIRT1 on OS rates based on regions (Asia: P < 0.001; non-Asia: P < 0.001), study size (small: P = 0.001, medium: P = 0.002, and large cohorts: P = 0.021), and specific cancer types (ovarian: P = 0.041, lung: P = 0.025, and gastric cancer: P = 0.025). However, no significant impact was observed in breast (P = 0.136) and colorectal cancers (P = 0.221). Overall, SIRT1 demonstrates consistent prognostic significance across various cancers and populations. However, the assessment of its long-term prognostic effects remains elusive, highlighting the need for further mechanistic research to guide targeted interventions and precision medicine in cancer therapy.

Keywords
Sirtuin
Prognosis
Cancer
Precision medicine
Oncology research
Funding
None.
Conflict of interest
Umair Ali Khan Saddozai and Xin-Ying Ji are members of the Editorial Board of this journal but were not involved in the editorial and peer-review processes for this paper, either directly or indirectly. Separately, the other authors declare that they have no known competing financial interests or personal relationships that could have influenced the work reported in this paper.
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