Hereditary angioedema: A case report
Angioneurotic edema (ANE) is a frequently encountered presentation in the emergency department. This condition manifests itself as sudden, unpredictable episodes of edema in cutaneous and mucosal tissues, commonly affecting the eyes, oral cavity, lips, and larynx. It is crucial to acknowledge that ANE is a component of a range of allergic manifestations, often associated with urticaria and occasionally of non-allergic origin. In some cases, this condition can lead to laryngeal edema, causing airway obstruction and potentially fatal consequences if not diagnosed in a timely manner. After 2007, the term ANE was replaced by the term angioedema (AE) in the literature for its conciseness and wider recognition. The purpose of this comprehensive article is to present a detailed analysis of a clinical case involving a 75-year-old patient diagnosed with AE, accompanied by a thorough examination of relevant literature that has significantly contributed to our understanding of this complex medical condition.
- Kahlon S, Lee C, Chirurgi R, Worku Hassen G. Angioneurotic edema associated with haloperidol. Case Rep Emerg Med. 2012;2012:725461. doi: 10.1155/2012/725461
- Maurer M, Magerl M, Ansotegui I, et al. The international WAO/EAACI guideline for the management of hereditary angioedema-the 2017 revision and update. Allergy. 2018;73(8):1575-1596. doi: 10.1111/all.13384
- Ohn MH, Wadhwa R. Angioneurotic Edema. In: StatPearls. Treasure Island, FL: StatPearls Publishing; 2022.
- Tarbox JA, Bansal A, Peiris AN. Angioedema. JAMA. 2018;319:2054. doi: 10.1001/jama.2018.4860
- Bernstein JA, Cremonesi P, Hoffmann TK, Hollingsworth J. Angioedema in the emergency department: A practical guide to differential diagnosis and management. Int J Emerg Med. 2017;10:15. doi: 10.1186/s12245-017-0141-z
- Kalambay J, Ghazanfar H, Martes Pena KA, Munshi RA, Zhang G, Patel JY. Pathogenesis of drug induced non-allergic angioedema: A review of unusual etiologies. Cureus. 2017;9:e1598. doi: 10.7759/cureus.1598
- Hébert J, Boursiquot JN, Chapdelaine H, et al. Bradykinin-induced angioedema in the emergency department. Int J Emerg Med. 2022;15:15. doi: 10.1186/s12245-022-00408-6
- Jayasinghe M, Caldera D, Prathiraja O, et al. A comprehensive review of bradykinin-induced angioedema versus histamine-induced angioedema in the emergency department. Cureus. 2022;14:e32075 doi: 10.7759/cureus.32075
- Honda D, Ohsawa I, Iwanami K, Rinno H, Tomino Y, Suzuki Y. A case of hereditary angioedema due to C1-inhibitor deficiency with recurrent abdominal pain diagnosed 40 years after the occurrence of the initial symptom. Clin J Gastroenterol. 2021;14:1175-1179. doi: 10.1007/s12328-021-01338-1
- Ohsawa I, Honda D, Nagamachi S, et al. Clinical manifestations, diagnosis, and treatment of hereditary angioedema: Survey data from 94 physicians in Japan. Ann Allergy Asthma Immunol. 2015;114(6):492-498. doi: 10.1016/j.anai.2015.03.01
- Henao M, Kraschnewski J, Kelbel T, Craig TJ. Diagnosis and screening of patients with hereditary angioedema in primary care. Ther Clin Risk Manag. 2016;12:701-711. doi: 10.2147/TCRM.S86293
- Zanichelli A, Magerl M, Longhurst H, et al. Hereditary angioedema with C1 inhibitor deficiency: Delay in diagnosis in Europe. Allergy Asthma Clin Immunol. 2013;9:29. doi: 10.1186/1710-1492-9-29
- Rubinstein E, Stolz L, Shefer A, Stevens C, Bousvaros A. Abdominal attacks and treatment in hereditary angioedema with C1-inhibitor deficiency. BMC Gastroenterol. 2014;14:71. doi: 10.1186/1471-230X-14-71
- Zuraw BL, Christiansen SC. HAE Pathophysiology and underlying mechanisms. Clin Rev Allergy Immunol. 2016;51:216-229. doi: 10.1007/s12016-016-8561-8
- Maurer M, Aberer W, Bouillet L, et al. Hereditary angioedema attacks resolve faster and are shorter after early icatibant treatment. PLoS One. 2013;8:e53773. doi: 10.1371/journal.pone.0053773
- Boccon-Gibod I, Bouillet L. Safety and efficacy of Icatibant self-administration for acute hereditary angioedema. Clin Exp Immunol. 2012;168:303-307. doi: 10.1111/j.1365-2249.2012.04574.x
- Zotter Z, Csuka D, Szabó E, et al. The influence of trigger factors on hereditary angioedema due to C1-inhibitor deficiency. Orphanet J Rare Dis. 2014;9:44. doi: 10.1186/1750-1172-9-44
- Craig T, Riedl M, Dykewicz MS, et al. When is prophylaxis for hereditary angioedema necessary? Ann Allergy Asthma Immunol. 2009;102:366-372. doi: 10.1016/S1081-1206(10)60506-6
- Bouillet L. Hereditary angioedema: A therapeutic revolution. Rev Med Interne. 2012;33:150-154. doi: 10.1016/j.revmed.2011.12.005