AccScience Publishing / MI / Online First / DOI: 10.36922/mi.3267
REVIEW ARTICLE

ABO blood type and cancer susceptibility: Unraveling the complex relationship

Prashanna Koirala1 Chhiring Sherpa2 Rebecca Dangol3 Salina Hona4 Saroj Nepal1 Prabin Dawadi1,5*
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1 Department of Biology, University of Mississippi, Mississippi, United States of America
2 Experimental Hematology and Cancer Biology, Cincinnati Children’s Hospital Medical Center, Ohio, United States of America
3 Department of Biotechnology, SANN International College, Purbanchal University, Kathmandu, Bagmati, Nepal
4 Division of Neurology, Cincinnati Children’s Hospital Medical Center, Ohio, United States of America
5 Department of Microbiology, Tribhuvan University, Kirtipur, Bagmati, Nepal
Submitted: 26 March 2024 | Revised: 24 October 2024 | Accepted: 12 November 2024 | Published: 31 December 2024
© 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

Different human diseases have been associated with specific blood groups. Numerous studies have promulgated their findings regarding the probable onset of various cancers based on the type of ABO blood group. However, the findings have been conflicting. This review primarily aims to summarize research findings from around the world to investigate the relationship between the risk of cancer occurrence and ABO blood group. Google Scholar, PubMed, Research4Life, and Web of Science were searched to identify relevant papers published before January 2023. Research papers related to common types of cancers were adequately and critically studied to determine the link between ABO blood groups and the risk of developing cancers. The results were ambiguous, as the findings were inconsistent regarding the relationship between ABO blood groups and cancer development. Therefore, more comprehensive research is needed to validate this relationship. This mini-systematic review emphasizes the need for additional thorough investigations to establish a clear correlation because of the inconsistent results.

Keywords
ABO
blood group
cancer risk
relationship
Funding
None.
Conflict of interest
The authors declare no conflict of interest.
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Microbes & Immunity, Electronic ISSN: 3029-2883 Print ISSN: 3041-0886, Published by AccScience Publishing