Dear Colleagues,

Neurodegenerative and neuromuscular diseases, such as Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis (ALS), and Duchenne muscular dystrophy, represent significant global health challenges. These conditions are often characterized by progressive neuronal or muscular dysfunction, resulting in severe disability and reduced quality of life. Despite substantial advancements in medical research, effective treatments remain limited. Understanding the biochemical pathways underlying these diseases is essential for identifying novel therapeutic targets.

This special issue aims to provide a comprehensive overview of recent advances in understanding the molecular mechanisms of neurodegenerative and neuromuscular diseases, with a focus on identifying emerging therapeutic targets. By bringing together cutting-edge research, the issue seeks to foster collaboration and innovation in developing effective interventions.

The special issue will feature original research articles, reviews, and perspectives on the following topics:

1. Molecular mechanisms:

Dysregulated signaling pathways in neurodegeneration and muscle degeneration.

Role of mitochondrial dysfunction, oxidative stress, and inflammation.

Mechanisms of protein aggregation and clearance.

2. Emerging therapeutic targets:

Small molecules targeting specific enzymes or pathways.

RNA-based therapies, including antisense oligonucleotides and RNA interference.

Advances in gene-editing technologies (e.g., CRISPR-Cas9).

Immunotherapy approaches targeting misfolded proteins or neuroinflammation.

3.Biomarkers and diagnostics:

Development of molecular biomarkers for early diagnosis and disease monitoring.

Role of imaging techniques in understanding disease progression.

4. Preclinical and clinical studies:

Translational studies bridging laboratory findings to clinical applications.

Lessons learned from recent clinical trials.