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REVIEW

Insights into phage therapy for Mycobacterium infections

Yuhan Wang1† ,  Sensen Hu1† ,  Yu Sun1† ,  Xinying Ji1 ,  Kunhou Yao1* ,  Tieshan Teng1*
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1 Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan, China
GPD 2024, 3(3), 2935 https://doi.org/10.36922/gpd.2935
Submitted: 14 February 2024 | Accepted: 18 June 2024 | Published: 10 September 2024
© 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

The irrational use of antibiotics has led to the persistent emergence of multi-drug-resistant bacteria, extensively drug-resistant bacteria, and even “superbugs,” pushing humanity toward a “post-antibiotic era” devoid of effective antibiotics. Consequently, the quest for novel treatment strategies has become an urgent priority. Bacteriophages, which are viruses that infect bacteria, originate from a variety of sources and exhibit high host specificity. This makes them an exceptional alternative to antibiotics, offering superior bactericidal efficacy. Their unique characteristics provide a novel approach to treating drug-resistant bacterial infections, offering a promising avenue for improving human health. Mycobacteriophages are a specific family of bacteriophages that parasitize bacteria of the genus Mycobacterium and are ubiquitously distributed in nature. They play a crucial role in regulating mycobacterial infection and advancing antimicrobial therapy. This review provides a comprehensive introduction to the structure, infection mechanism, clinical applications, phage resistance, and research progress of mycobacteriophages. The aim is to enhance our understanding of their characteristics and potential applications in biomedicine, providing a comprehensive reference for related research.

Keywords
Drug-resistant bacteria
Mycobacteriophage
Phage-resistant strains
Biological characteristics
Applications
Funding
This research was funded by the Key R&D and Promotion Projects of Henan Province (232102311139); China Postdoctoral Science Foundation (2021m690095); and the National Innovation and Entrepreneurship Training Program for College Students (20237003005 and 20231022001).
Conflict of interest
The authors declare that they have no competing interests.
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