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REVIEW

Long non-coding RNAs: A trained immunity perspective

Bikesh Kumar Nirala1 ,  Gauri Shishodia2 ,  Praveen Kumar3 ,  Ravi Shankar Singh4*
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1 Department of Pediatrics, School of Medicine, Emory University, Atlanta, Georgia, United States of America
2 Department of Biochemistry, UT Southwestern Medical Centre, Dallas, Texas, United States of America
3 Department of Neurology, UT Southwestern Medical Centre, Dallas, Texas, United States of America
4 Department of Pathology, Division of Microbiology and Immunology University of Utah, Emma Eccles Jones Medical Research Building, Salt Lake City, Utah, United States of America
GPD 2024, 3(2), 2791 https://doi.org/10.36922/gpd.2791
Submitted: 20 January 2024 | Accepted: 29 April 2024 | Published: 4 June 2024
© 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

The conventional understanding of immunological memory within adaptive immunity has faced recent challenges, paving the way for a novel concept known as “trained immunity.” This phenomenon revolves around the epigenetic and metabolic reprogramming of cells as its central components. A growing body of evidence suggests that long non-coding RNAs (lncRNAs) play a crucial role in regulating immune cell development, function, and response to various diseases. Through intricate protein-protein interactions and interactions with DNA and RNA, lncRNAs significantly contribute to the modulation of immune processes. However, our comprehension of the involvement of lncRNAs in trained immunity is still in its early stages. This review delves into the recent advancements in lncRNA research, focusing on their diverse functions in immune cell development, host-pathogen interactions, potential processes, and their biological significance in trained immunity. Special attention is given to the role of lncRNAs in altering chromatin structure, orchestrating chromosomal looping, and driving metabolic reprogramming within cells.

Keywords
Long non-coding RNA
Trained immunity
Metabolic reprogramming
Epigenetics
Funding
None.
Conflict of interest
The authors declare that they have no competing interests.
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