Gene & Protein in Disease (GPD) is pleased to present the Editor’s Choice Articles in 2025. Editor’s Choice Articles are based on the recommendations of the GPD editorial team from around the world. Editors select a small number of articles published in GPD that they believe will be particularly interesting to readers, or otherwise important in the respective research area. The aim in highlighting and promoting this research is to provide a snapshot of some of the most exciting work published in the various topical areas of Gene and Protein in Disease.

1. EDITORIAL

Circadian rhythms in Alzheimer’s disease: A molecular clock worth watching

by Bivek Singh

Gene & Protein in Disease 2025, 4(3), 025160031 https://doi.org/10.36922/GPD025160031

2. REVIEW ARTICLE

Exploring the multifaceted roles of adenosine: A molecule with diverse functions

by Jacqueline Fátima Martins de Almeida, Martina Contestabile, Simona Daniele

Gene & Protein in Disease 2025, 4(4), 8575 https://doi.org/10.36922/gpd.8575

3. REVIEW ARTICLE

The importance of phylogenetic studies in the evolution of beta-lactamases: Tracing antimicrobial resistance in priority pathogens

by Ananya Anurag Anand, Vidushi Yadav, Sarfraz Anwar, K. Kshitiz, ... Sintu Kumar Samanta

Gene & Protein in Disease 2025, 4(4), 8278 https://doi.org/10.36922/gpd.8278

4. ORIGINAL RESEARCH ARTICLE

Identification of hub genes in breast cancer through genome-wide association and functional analyses of M2-like tumor-associated macrophages

by Guang Yang, Zhaorui Hao, Xingrui Liu, Zixi Tang

Gene & Protein in Disease 2025, 4(4), 025250050 https://doi.org/10.36922/GPD025250050

5. ORIGINAL RESEARCH ARTICLE

Identification of cullin family members as novel diagnostic and prognostic biomarkers in kidney renal clear cell carcinoma

By Shaohao Liu, Fei Wang, Yange Wang, Dandan Wang, ... Na Fang

Gene & Protein in Disease 2025, 4(3), 025070014 https://doi.org/10.36922/GPD025070014

6. SHORT COMMUNICATION

B-cell lymphoma/leukemia 11A transcriptional targets and chromatin binding patterns in human leukemias

by Joseph D. Dekker, Alessandra M. Araujo, Haley O. Tucker

Gene & Protein in Disease 2025, 4(2), 8131 https://doi.org/10.36922/gpd.8131

7. ORIGINAL RESEARCH ARTICLE

Correlation between SIRT1 expression and overall survival across various cancers: A meta-analysis

by Mehreen Iftikhar,Sana Tanveer, Samyyia Abrar, Amna Rehman, ... Muhammad Babar Khawar

Gene & Protein in Disease 2025, 4(1), 4294 https://doi.org/10.36922/gpd.4294

8. ORIGINAL RESEARCH ARTICLE

FXR1 modulates the expression of oncogenes and tumor suppressor genes associated with poor cancer prognosis

by Faiz Ali Khan, Xin-Ying Ji, Shaoping Ji, Jingcheng Dong

Gene & Protein in Disease 2025, 4(1), 5068 https://doi.org/10.36922/gpd.5068