AccScience Publishing / GPD / Volume 2 / Issue 3 / DOI: 10.36922/gpd.1320
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CASE REPORT

Multisystem inflammatory syndrome in adult with longitudinally extensive transverse myelitis following SARS-CoV-2 vaccination: A case report

Anirban Gupta1* Sudheer Pandey1 Pawan Dhull1 Amit Sreen1 Satish Barki1 Krishna Kumar2 Kompella Kiran Kumar3
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1 Department of Neurology, Army hospital (R&R), New Delhi, India
2 Department of Anesthesia and Critical Care, Army hospital (R&R), New Delhi, India
3 Department of Internal Medicine, Army hospital (R&R), New Delhi, India
Submitted: 18 July 2023 | Accepted: 5 September 2023 | Published: 29 September 2023
© 2023 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

Multisystem inflammatory syndrome in adults (MIS-A) is a known complication arising after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or vaccination. However, longitudinal extensive transverse myelitis (LETM), which is a neurological manifestation of MIS-A, is rarely reported among individuals after SARS-CoV-2 infection or vaccination. Here, we present a case of a 38-year-old female, with a history of SARS-CoV-2 infection in May 2021 and subsequent SARS-CoV-2 vaccination (on November 1, 2021; COVISHIELD™, ChAdOx1 nCoV-19 Corona Virus Vaccine), who presented with acute flaccid quadriparesis with bowel and bladder involvement since December 26, 2021. While being treated in the hospital, she developed fever, rash, shock, myocarditis, breathlessness, jaundice, and acute kidney injury. Magnetic resonance Imaging revealed LETM. She was negative for SARS-CoV-2 infection and showed raised in SARS-CoV-2 antibody titer. Thus, she was diagnosed as having MIS-A with LETM and managed with Intravenous Immunoglobulin, antibiotics, hemodialysis, and steroids with improvement.

Keywords
Severe acute respiratory syndrome coronavirus 2
Multisystem inflammatory syndrome in adults
Vaccination
Flaccid quadriparesis
Longitudinal extensive transverse myelitis
Funding
None.
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Conflict of interest
The authors declare they have no competing interests.
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Gene & Protein in Disease, Electronic ISSN: 2811-003X Published by AccScience Publishing