AccScience Publishing / GPD / Volume 1 / Issue 2 / DOI: 10.36922/gpd.v1i2.147
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Insights into the role of RUNX1 gene in female-related cancers

Sagarika Shahriar1† Zarin Tasnim Rafa1† Maiesha Samiha Mahmood1† Deera Mahasin1† Yusha Araf2† Md. Asad Ullah3 MD. Hasanur Rahman4 Md. Akkas Ali5 Fatama Tous Zohora6 Chunfu Zheng7,8* Mohammad Jakir Hosen5*
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1 Biotechnology Program, Department of Mathematics and Natural Sciences, School of Data and Sciences, Brac University, Dhaka, Bangladesh
2 Department of Biotechnology Agricultural University, Mymensingh 2202, Bangladesh
3 Department of Biotechnology and Genetic Engineering, Faculty of Biological Sciences, Jahangirnagar University, Savar, Dhaka, Bangladesh
4 Department of Biotechnology and Genetic Engineering, Faculty of Life Sciences, Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalganj, Bangladesh
5 Department of Genetic Engineering and Biotechnology, School of Life Sciences, Shahjalal University of Science and Technology, Sylhet, Bangladesh
6 Department of Biotechnology and Genetic Engineering, Faculty of Life Science, Mawlana Bhashani Science and Technology University, Tangail 1902, Bangladesh
7 Department of Immunology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China
8 Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Alberta, Canada
Submitted: 4 July 2022 | Accepted: 12 October 2022 | Published: 2 November 2022
© 2022 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

The transcription factors of runt-related transcription factor (RUNX) are important regulators of various developmental pathways, with roles in proliferation, differentiation, apoptosis, and cell lineage. One of the core subclasses of the RUNX family that codes for a number of transcription-binding proteins is the RUNX1 gene, which is located on chromosome 21q22.12. There has been extensive research on RUNX1 mutations in hematological cancers, where the most conspicuous position of several chromosomal translocations has drawn interest as a tumor suppressor. In this paper, the malignancies triggered by RUNX1 mutations, which are strongly associated with cancers of the female reproductive system, along with their diagnoses and potential treatments, are reviewed. It has been found that RUNX1 mutation plays a pervasive function in female health, including sex determination, follicular development, steroidogenesis, and the interaction of the estrogen system. In contrast, chromosomal translocations in the gene linked to RUNX1 mutation may lead to severe malignancies in females. Breast, ovarian, uterine, and cervical cancers have shown the highest frequency of genetic abnormalities in the RUNX1 gene. The second most common cause of cancer-related mortality in women is breast cancer, which is also the most common cancer. There is an opposing relationship between uterine cancer and low-grade tumors that often remain confined to the uterus. Due to the regular occurrence of promoter hypermethylation and hypomethylation changes, ovarian cancer has become the most fatal of all gynecological tumors. Finally, despite being the cancer least likely to result from RUNX1 mutation, cervical cancer can directly impair natural killer cell activity. Both hematopoietic and non-hematopoietic cancer cells can form and become tumors when the RUNX1 gene is mutated, with female malignancies being the primary target. Therefore, more research on RUNX1 gene’s pattern of expression, both in vitro and in silico, is needed to lower the incidence of female-related cancers.

Keywords
RUNX1
Chromosomal translocation
Breast cancer
Uterine cancer
Ovarian cancer
Cervical cancer
Funding
The authors received no funding from external sources.
Conflict of interest
The authors declare that they have no known competing financial interests or personal relationships that could have influenced the work reported in this paper.
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