The resurgence of phage therapy as a potent countermeasure against antimicrobial resistance has been accompanied by significant challenges in patent protection. This perspective paper examines the patentability of natural phages as therapeutics, focusing on the United States and extending to the European Union and Australia – jurisdictions at the forefront of this biotechnological innovation. We dissect the legal frameworks and identify the patent claims that have successfully navigated the complex intellectual property landscape. Our analysis reveals a dichotomy between the natural origin of therapeutic phages and the inventive steps required for patent eligibility. Despite hurdles, we highlight strategic innovations and specific patent claims that have been granted, suggesting a path forward for the commercialization and protection of phage therapy. We conclude with a call for a more adaptive legal framework to foster innovation and recognize the transformative potential of phage therapy in modern medicine.