Singapore Centre for 3D Printing, Nanyang Technological University, SingaporeInterface of biology & engineering (Engineering in Biology); Materials science & engineering; Mechanical & manufacturing engineering
Since August 2021, Paulo Bartolo is Professor at the School of Mechanical and Aerospace Engineering at Nanyang Technological University and Executive Director of the Singapore Centre for 3D Printing.
In February 2014 he joined the University of Manchester (UK) as Chair Professor on Advanced Manufacturing. At the University of Manchester, Paulo Bartolo was the Head of the Manufacturing Group, Leader of the Innovative Manufacturing Research Theme, Member of the Department of Mechanical, Aerospace and Civil Engineering Executive Committee and Member of the Departmental Committee for the Research Excellence Framework 2021 (REF21) Engineering Unit of Assessment 12 (UOA 12). He was also member of the Senior Leadership Team (SLT) Committee (2014-2017) and member of the Promotion Committee (2014-2017). At the University of Manchester he was also the Industry 4.0 Academic Lead; member of the Advanced Manufacturing Strategic Oversight Group; member of the Management Board of the EPSRC & MRC Centre for Doctoral Training (CDT) in Regenerative Medicine; theme leader of the “Industry 4.0” Societal Challenge area within the Digital Futures; and member of the Thomas Ashton Institute (Academic Lead for Industry 4.0 – implications for health and safety).
Paulo Bartolo was the founder and Director of the Centre for Rapid and Sustainable Product Development (2007-2013) at the Polytechnic Institute of Leiria (Portugal), a Research Centre of Excellence in Mechanical Engineering of the Portuguese Foundation for Science and Technology. At the Polytechnic Institute of Leiria he was Head of the Mechanical Engineering Department (2001-2009); President of the Research Assessment Committee (2009-2013); President of the Scientific Council for Research, Development and Advanced Studies (2009-2013).
He is a Fellow of CIRP (The International Academy of Production Engineering) and served the Academy as Chairman of the CIRP Scientific Technical Committee on Electro-Physical and Chemical Processes (STC E) (2016-2019) and as Vice-Chairman of STC E (2013-2016) and Vice-Chairman of the CIRP Collaborative Working Group on Biomanufacturing (2010-2012). Paulo Bartolo is also Advisor of the Brazilian Institute of Biofabrication (INCT-BIOFABRIS) funded by the Brazilian Government.
Nanomaterials are attracting great interest for several biomedical applications. Nanomaterial features like particle morphology (size, thickness, shape) and physicochemical properties play a crucial role in the biological effect of nanomaterials and can be tuned to achieve the desired therapeutic outcomes. Modification of surface properties by altering the chemistry and/or loading of biologically active molecules and drugs can also be performed as effective strategies to improve selectivity and modulate cellular responses. Moreover, nanomaterials have been explored to design multifunctional (bio)inks for the (bio)printing of 3D constructs capable of modulating cell fate and allowing multistage drug release.
This special issue (SI) aims to gather papers discussing the most recent advances in the development of nanomaterials for biomedical applications with emphasis on the use of bioprinting as enabling technologies to create functional constructs. The SI is open to original research articles and review papers covering the following topics:
- Preparation and characterization of nanomaterials for 3D bioprinting, including 2D-nanomaterials, metallic, polymeric, lipid-based nanoparticles, metalic-organic frameworks, self-assembled nanoparticles, among others.
- Surface modification of nanomaterials, including the functionalization with targeting molecules, antibodies, or/and immunotherapy agents.
- Design, bioprinting and characterization of (bio)inks containing nanomaterials and the characterization of bioprinted constructs.
- Development of photoresponsive nanomaterials comprising the optimization of their properties and the understanding of the mechanisms that govern their photothermal and/or photodynamic properties.
- New magnetic hyperthermia therapy agents, based on nanomaterials, with improved magnetic properties, biocompatibility, and therapeutic effects.
- Biological interaction between bioprinted nanomaterials, cells and tissues.
Bioprinting of nanomaterials for tissue regeneration, immunomodulation, multistage drug delivery and cancer therapy.
Development and in vitro evaluation of bioprinted plasma-infused biocarriers for mesenchymal stromal cell delivery in musculoskeletal disorder treatment
Collagen-sodium alginate-silk fibroin 3D-printed scaffold loaded with polydatin promotes cartilage regeneration by improving lipid metabolism and cell apoptosis
3D printing technology: Driving pioneering innovations in anti-cancer drug delivery systems
Neural cell responses to spinal implant biomaterials in a 3D-bioprinted cell culture model