AccScience Publishing / IJB / Online First / DOI: 10.36922/IJB025360364
REVIEW ARTICLE
Early Access

Skin bioprinting for burn reconstruction: from stem cell integration to in situ smart regenerative systems

Aline Yen Ling Wang1* Ana Elena Aviña1,2 Yen-Yu Liu1 Huang-Kai Kao3,4
Show Less
1 Center for Vascularized Composite Allotransplantation, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
2 International PhD Program in Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan
3 Department of Plastic and Reconstructive Surgery, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
4 College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
Received: 3 September 2025 | Accepted: 29 September 2025 | Published online: 29 September 2025
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

The bioprinting of smart skin is emerging as a versatile platform not only for the coverage of wounds, but for potential sensory regeneration, monitoring of structures in real time, and tissue repairs. This review presents a coherent road map to bridge the biofabrication science and clinical translation. We discuss the investigation into piezoelectric scaffolds, conductive polymers and stimuli-responsive inks in preclinical environments to produce functional features such as thermal and tactile sensing. Early clinical case reports have proven the concept of in vitro skin bioprinting strategies, such as skin patches printed for patient-specific applications with minimally manipulated autologous extracellular matrix or umbilical cord mesenchymal stem cells-laden hydrogels, for the management of chronic wounds. In parallel, several preclinical in situ bioprinting studies with handheld or microfluidic-assisted devices have shown promising results in full-thickness diabetic and burn wound models in terms of enhanced re-epithelisation and neovascularization. We also present inherent differences between in vitro bioprinting of autologous dermo-epithelial substitutions and in situ strategies based on AI-guided print path generation and wound topography mapping. Although sensor-equipped bioprinted grafts with promising results, they are still at an early development stage and await validation in large-scale clinical trials. Nevertheless, integration of stem cell technologies, smart biomaterials, and bio-intelligent control systems may eventually be used to support bioprinted skin constructs not only as replacement tissue, but also as potential living, sensing interfaces. This broad multidisciplinary convergence may be helpful in redefining skin repair by allowing dynamic interaction between engineered skin grafts and skin host tissue physiology.

Keywords
Skin bioprinting
Burn wound reconstruction
Stem cells
In situ bioprinting
Bioinks
Smart skin
Vascularization
Skin substitutes
Funding
This research was funded by grants from the National Science and Technology Council, Taiwan (NSTC 112-2314-B-182A-045-MY3), and the Chang Gung Medical Foundation, Chang Gung Memorial Hospital, Taiwan (CMRPG3M0283).
Conflict of interest
The authors declare they have no competing interests.
Share
Back to top
International Journal of Bioprinting, Electronic ISSN: 2424-8002 Print ISSN: 2424-7723, Published by AccScience Publishing