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Next-Gen Biofabrication: Innovations in 3D & 4D Bioprinting for Future-Ready Applications

Submission Deadline: 15 March 2026
Special Issue Editors
Nileshkumar Dubey
Department of Comprehensive Dentistry, School of Dentistry, University of Maryland, USA
Interests:

3D Bioprinting; Biomaterials; Bone Regeneration; Dentistry; Regenerative Medicine; Stem Cells; Tissue Engineering

Profile:

Clinical Assistant Professor at at University of Maryland, Baltimore
January 2014-January 2018 Ph.D. Candidate, Department of Oral Sciences, National University of Singapore
May 2018 – January 2021 Postdoctoral Fellow, Department of Cariology, University of Michigan
His current research focuses on the development of biomaterial for tissue engineering and regenerative medicine. Specifically, my research involves the development of novel hybrid bio-inks for 3D bioprinting the constructs containing living cells with a focus on applications in dental tissue regeneration.

Isaac J. de Souza Araújo
College of Dentistry, University of Saskatchewan, Canada
Interests:

3D Printing; Electrospinning; Dental Materials; Regeneration

Special Issue Information

Dear Colleagues:

We are pleased to invite submissions to our upcoming Special Issue titled “Next-Gen Biofabrication: Innovations in 3D & 4D Bioprinting for Future-Ready Applications.” This issue aims to spotlight the latest advances in biofabrication technologies that are revolutionizing the way we engineer living systems. With the growing demand for tissue-engineered constructs, organ-on-chip systems, and precision medicine, 3D and 4D bioprinting are rapidly emerging as transformative tools in biology and medicine.

This issue will cover developments in biomaterial-based scaffolds, stem cell-laden bioinks, and programmable tissue morphogenesis. We also welcome studies integrating microfluidics with bioprinting to mimic dynamic biological environments. Research that leverages machine learning for optimizing print fidelity or bioreactors for tissue maturation is also of high interest. Contributions may include original research, critical reviews, and technical innovations that bridge bioengineering and translational science.

This issue also aims to highlight ethical considerations, regulatory readiness, and clinical translatability of printed tissues and organs. Our goal is to gather a multidisciplinary collection of work from experts in cell biology, biomaterials, regenerative medicine, and computational biology. By fostering cross-disciplinary innovation, this Special Issue will serve as a platform to advance next-generation solutions for regenerative healthcare, disease modeling, and personalized therapeutics. Let us collectively shape the future of biofabrication biology—from bench to bedside.

Topics of interest include (but are not limited to):

  • Advanced materials for 3D and 4D bioprinting
  • Multi-material and multi-scale bioprinting approaches
  • Intelligent/smart systems and shape-morphing structures
  • 3D and 4D bioprinting for Biomedical and tissue engineering applications
  • Sustainability and circular economy in additive bio-manufacturing
  • Simulation, modeling, and digital twins in bioprinting processes
  • Hybrid bio-manufacturing and integration with traditional techniques
  • Industry 4.0 and AI-driven bio-design optimization
  • Case studies, reviews, and emerging applications of 3D and 4D bioprinting
Keywords
3D bioprinting; 4D bioprinting; stimuli-responsive hydrogels; tissue engineering; AI in bio-manufacturing; regenerative medicine; Industry 4.0
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International Journal of Bioprinting, Electronic ISSN: 2424-8002 Print ISSN: 2424-7723, Published by AccScience Publishing