1. Mahmoudian A, Lohmander LS, Mobasheri A, Englund M, Luyten FP. Early-stage symptomatic osteoarthritis of the knee - time for action. Nat Rev Rheumatol. 2021;17(10):621-632. doi: 10.1038/s41584-021-00673-4
2. He B, Wu JP, Kirk TB, Carrino JA, Xiang C, Xu J. High-resolution measurements of the multilayer ultra-structure of articular cartilage and their translational potential. Arthritis Res Ther. 2014;16(2):205. doi: 10.1186/ar4506
3. Soderquist M, Barnes L. Osteochondral allograft transplantation for articular humeral head defect from ballistic trauma. JSES Rev Rep Tech. 2024;4(3):540-546. doi: 10.1016/j.xrrt.2024.04.008
4. GBD 2021 Osteoarthritis Collaborators. Global, regional, and national burden of osteoarthritis, 1990-2020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021. Lancet Rheumatol. 2023;5(9):e508-e522. doi: 10.1016/s2665-9913(23)00163-7
5. Weng Q, Chen Q, Jiang T, et al. Global burden of early-onset osteoarthritis, 1990-2019: results from the Global Burden of Disease Study 2019. Ann Rheum Dis. 2024;83(7):915-925. doi: 10.1136/ard-2023-225324
6. Abdulghani S, Morouço PG. Biofabrication for osteochondral tissue regeneration: bioink printability requirements. J Mater Sci Mater Med. 2019;30(2):20. doi: 10.1007/s10856-019-6218-x
7. Brophy RH, Fillingham YA. AAOS clinical practice guideline summary: management of osteoarthritis of the knee (nonarthroplasty), third edition. J Am Acad Orthop Surg. 2022;30(9):e721-e729. doi: 10.5435/jaaos-d-21-01233
8. Medina J, Garcia-Mansilla I, Fabricant PD, Kremen TJ, Sherman SL, Jones K. Microfracture for the treatment of symptomatic cartilage lesions of the knee: a survey of International Cartilage Regeneration & Joint Preservation Society. Cartilage. 2021;13(1_suppl):1148s-1155s. doi: 10.1177/1947603520954503
9. Patel S, Caldwell JM, Doty SB, et al. Integrating soft and hard tissues via interface tissue engineering. J Orthop Res. 2018;36(4):1069-1077. doi: 10.1002/jor.23810
10. Lee CH, Cook JL, Mendelson A, Moioli EK, Yao H, Mao JJ. Regeneration of the articular surface of the rabbit synovial joint by cell homing: a proof of concept study. Lancet. 2010;376(9739):440-448. doi: 10.1016/s0140-6736(10)60668-x
11. Patel JM, Merriam AR, Culp BM, Gatt CJ, Jr., Dunn MG. One-year outcomes of total meniscus reconstruction using a novel fiber-reinforced scaffold in an ovine model. Am J Sports Med. 2016;44(4):898-907. doi: 10.1177/0363546515624913
12. Ayers DC. How common is revision for adverse reaction to metal debris after total hip replacement with a metal-on-polyethylene bearing surface?: commentary on an article by Anders Persson, MD, et al.: “Revision for Symptomatic Pseudotumor Following Primary Total Hip Arthroplasty with a Standard Femoral Stem”. J Bone Joint Surg Am. 2018;100(11):e82. doi: 10.2106/jbjs.18.00193
13. Ansari S, Khorshidi S, Karkhaneh A. Engineering of gradient osteochondral tissue: from nature to lab. Acta Biomater. 2019;87:41-54. doi: 10.1016/j.actbio.2019.01.071
14. Bedell ML, Wang Z, Hogan KJ, et al. The effect of multi-material architecture on the ex vivo osteochondral integration of bioprinted constructs. Acta Biomater. 2023;155:99-112. doi: 10.1016/j.actbio.2022.11.014
15. McKee TJ, Perlman G, Morris M, Komarova SV. Extracellular matrix composition of connective tissues: a systematic review and meta-analysis. Sci Rep. 2019;9(1):10542. doi: 10.1038/s41598-019-46896-0
16. Di Luca A, Szlazak K, Lorenzo-Moldero I, et al. Influencing chondrogenic differentiation of human mesenchymal stromal cells in scaffolds displaying a structural gradient in pore size. Acta Biomater. 2016;36:210-219. doi: 10.1016/j.actbio.2016.03.014
17. Shen G. The role of type X collagen in facilitating and regulating endochondral ossification of articular cartilage. Orthod Craniofac Res. 2005;8(1):11-17. doi: 10.1111/j.1601-6343.2004.00308.x
18. Horkay F, Basser PJ, Geissler E. Cartilage extracellular matrix polymers: hierarchical structure, osmotic properties, and function. Soft Matter. 2024;20(30):6033-6043. doi: 10.1039/d4sm00617h
19. Rose FR, Oreffo RO. Bone tissue engineering: hope vs hype. Biochem Biophys Res Commun. 2002;292(1):1-7. doi: 10.1006/bbrc.2002.6519
20. Gonzalez-Fernandez T, Rathan S, Hobbs C, et al. Pore-forming bioinks to enable spatio-temporally defined gene delivery in bioprinted tissues. J Control Release. 2019;301:13-27. doi: 10.1016/j.jconrel.2019.03.006
21. Rowland CR, Glass KA, Ettyreddy AR, et al. Regulation of decellularized tissue remodeling via scaffold-mediated lentiviral delivery in anatomically-shaped osteochondral constructs. Biomaterials. 2018;177:161-175. doi: 10.1016/j.biomaterials.2018.04.049
22. Liu Y, Huang C, Bai M, Pi C, Zhang D, Xie J. The roles of Runx1 in skeletal development and osteoarthritis: a concise review. Heliyon. 2022;8(12):e12656. doi: 10.1016/j.heliyon.2022.e12656
23. Li W, Zhang S, Liu J, Liu Y, Liang Q. Vitamin K2 stimulates MC3T3‑E1 osteoblast differentiation and mineralization through autophagy induction. Mol Med Rep. 2019;19(5):3676-3684. doi: 10.3892/mmr.2019.10040
24. Grogan SP, Duffy SF, Pauli C, et al. Zone-specific gene expression patterns in articular cartilage. Arthritis Rheum. 2013;65(2):418-428. doi: 10.1002/art.37760
25. Zuscik MJ, Hilton MJ, Zhang X, Chen D, O’Keefe RJ. Regulation of chondrogenesis and chondrocyte differentiation by stress. J Clin Invest. 2008;118(2):429-438. doi: 10.1172/jci34174
26. Ma J, Wang Z, Zhao J, Miao W, Ye T, Chen A. Resveratrol attenuates lipopolysaccharides (LPS)-induced inhibition of osteoblast differentiation in MC3T3-E1 cells. Med Sci Monit. 2018;24:2045-2052. doi: 10.12659/msm.905703
27. Kitaura H, Marahleh A, Ohori F, et al. Osteocyte-related cytokines regulate osteoclast formation and bone resorption. Int J Mol Sci. 2020;21(14):5169. doi: 10.3390/ijms21145169
28. Zhang D, Deng X, Liu Y, et al. MMP-10 deficiency effects differentiation and death of chondrocytes associated with endochondral osteogenesis in an endemic osteoarthritis. Cartilage. 2022;13(3):19476035221109226. doi: 10.1177/19476035221109226
29. Boyce BF, Xing L. Functions of RANKL/RANK/OPG in bone modeling and remodeling. Arch Biochem Biophys. 2008;473(2):139-146. doi: 10.1016/j.abb.2008.03.018
30. Quinn TM, Häuselmann HJ, Shintani N, Hunziker EB. Cell and matrix morphology in articular cartilage from adult human knee and ankle joints suggests depth-associated adaptations to biomechanical and anatomical roles. Osteoarthritis Cartilage. 2013;21(12):1904-1912.
31. Niu H, Liu C, Li A, et al. Relationship between triphasic mechanical properties of articular cartilage and osteoarthritic grade. Sci China Life Sci. 2012;55(5):444-451.

doi: 10.1007/s11427-012-4326-7

32. Sun Y, Zhang K, Dong H, et al. Layered mechanical and electrical properties of porcine articular cartilage. Med Biol Eng Comput. 2022;60(10):3019-3028. doi: 10.1007/s11517-022-02653-6
33. Burr DB, Gallant MA. Bone remodelling in osteoarthritis. Nat Rev Rheumatol. 2012;8(11):665-673. doi: 10.1038/nrrheum.2012.130
34. Flachsmann ER, Broom ND, Oloyede A. A biomechanical investigation of unconstrained shear failure of the osteochondral region under impact loading. Clin Biomech (Bristol). 1995;10(3):156-165. doi: 10.1016/0268-0033(95)93706-y
35. Madry H, van Dijk CN, Mueller-Gerbl M. The basic science of the subchondral bone. Knee Surg Sports Traumatol Arthrosc. 2010;18(4):419-433. doi: 10.1007/s00167-010-1054-z
36. Broom ND, Oloyede A, Flachsmann R, Hows M. Dynamic fracture characteristics of the osteochondral junction undergoing shear deformation. Med Eng Phys. 1996;18(5):396-404. doi: 10.1016/1350-4533(95)00067-4
37. Mieloch AA, Richter M, Trzeciak T, Giersig M, Rybka JD. Osteoarthritis severely decreases the elasticity and hardness of knee joint cartilage: a nanoindentation study. J Clin Med. 2019;8(11):1865. doi: 10.3390/jcm8111865
38. Davis S, Zekonyte J, Karali A, Roldo M, Blunn G. Early degenerative changes in a spontaneous osteoarthritis model assessed by nanoindentation. Bioengineering (Basel). 2023;10(9):995. doi: 10.3390/bioengineering10090995
39. Peters AE, Akhtar R, Comerford EJ, Bates KT. The effect of ageing and osteoarthritis on the mechanical properties of cartilage and bone in the human knee joint. Sci Rep. 2018;8(1):5931. doi: 10.1038/s41598-018-24258-6
40. Hu YJ, Yu YE, Cooper HJ, et al. Mechanical and structural properties of articular cartilage and subchondral bone in human osteoarthritic knees. J Bone Miner Res. 2024;39(8):1120-1131. doi: 10.1093/jbmr/zjae094
41. Guo J, Li Q, Zhang R, et al. Loose pre-cross-linking mediating cellulose self-assembly for 3D printing strong and tough biomimetic scaffolds. Biomacromolecules. 2022;23(3):877-888. doi: 10.1021/acs.biomac.1c01330
42. Zhang X, Liu Y, Zuo Q, et al. 3D bioprinting of biomimetic bilayered scaffold consisting of decellularized extracellular matrix and silk fibroin for osteochondral repair. Int J Bioprint. 2021;7(4):401. doi: 10.18063/ijb.v7i4.401
43. Nedrelow DS, Rassi A, Ajeeb B, et al. Regenerative engineering of a biphasic patient-fitted temporomandibular joint condylar prosthesis. Tissue Eng Part C Methods. 2023;29(7):307-320. doi: 10.1089/ten.TEC.2023.0093
44. Wu Z, Yao H, Sun H, et al. Enhanced hyaline cartilage formation and continuous osteochondral regeneration via 3D-Printed heterogeneous hydrogel with multi-crosslinking inks. Mater Today Bio. 2024;26:101080. doi: 10.1016/j.mtbio.2024.101080
45. Diloksumpan P, de Ruijter M, Castilho M, et al. Combining multi-scale 3D printing technologies to engineer reinforced hydrogel-ceramic interfaces. Biofabrication. 2020;12(2):025014. doi: 10.1088/1758-5090/ab69d9
46. Liu Y, Peng L, Li L, et al. 3D-bioprinted BMSC-laden biomimetic multiphasic scaffolds for efficient repair of osteochondral defects in an osteoarthritic rat model. Biomaterials. 2021;279:121216. doi: 10.1016/j.biomaterials.2021.121216
47. Gao J, Ding X, Yu X, et al. Cell-free bilayered porous scaffolds for osteochondral regeneration fabricated by continuous 3d-printing using nascent physical hydrogel as ink. Adv Healthc Mater. 2021;10(3):e2001404. doi: 10.1002/adhm.202001404
48. Wang Z, Cao W, Wu F, et al. A triphasic biomimetic BMSC-loaded scaffold for osteochondral integrated regeneration in rabbits and pigs. Biomater Sci. 2023;11(8):2924-2934. doi: 10.1039/d2bm02148j
49. Braxton T, Lim K, Alcala-Orozco C, et al. Mechanical and physical characterization of a biphasic 3D printed silk-infilled scaffold for osteochondral tissue engineering. ACS Biomater Sci Eng. 2024;10(12):7606-7618. doi: 10.1021/acsbiomaterials.4c01865
50. Wang S, Luo B, Bai B, et al. 3D printed chondrogenic functionalized PGS bioactive scaffold for cartilage regeneration. Adv Healthc Mater. 2023;12(27): e2301006. doi: 10.1002/adhm.202301006
51. Wang H, Zhang J, Bai H, et al. 3D printed cell-free bilayer porous scaffold based on alginate with biomimetic microenvironment for osteochondral defect repair. Biomater Adv. 2025;167:214092. doi: 10.1016/j.bioadv.2024.214092
52. Ding X, Gao J, Yu X, et al. 3D-printed porous scaffolds of hydrogels modified with TGF-β1 binding peptides to promote in vivo cartilage regeneration and animal gait restoration. ACS Appl Mater Interfaces. 2022;14(14):15982-15995. doi: 10.1021/acsami.2c00761
53. Li Q, Yu H, Zhao F, et al. 3D printing of microenvironment-specific bioinspired and exosome-reinforced hydrogel scaffolds for efficient cartilage and subchondral bone regeneration. Adv Sci (Weinh). 2023;10(26):e2303650. doi: 10.1002/advs.202303650
54. Cui X, Alcala-Orozco CR, Baer K, et al. 3D bioassembly of cell-instructive chondrogenic and osteogenic hydrogel microspheres containing allogeneic stem cells for hybrid biofabrication of osteochondral constructs. Biofabrication. 2022;14(3):034101. doi: 10.1088/1758-5090/ac61a3
55. Wei W, Liu W, Kang H, et al. A one-stone-two-birds strategy for osteochondral regeneration based on a 3D printable biomimetic scaffold with kartogenin biochemical stimuli gradient. Adv Healthc Mater. 2023;12(15):e2300108. doi: 10.1002/adhm.202300108
56. Coyle A, Chakraborty A, Huang J, Shamiya Y, Luo W, Paul A. In vitro engineered ECM-incorporated hydrogels for osteochondral tissue repair: a cell-free approach. Adv Healthc Mater. 2025;14(4):e2402701. doi: 10.1002/adhm.202402701
57. Sun T, Feng Z, He W, et al. Novel 3D-printing bilayer GelMA-based hydrogel containing BP,β-TCP and exosomes for cartilage-bone integrated repair. Biofabrication. 2023;16(1):015008. doi: 10.1088/1758-5090/ad04fe
58. Eckstein KN, Hergert JE, Uzcategui AC, et al. Controlled mechanical property gradients within a digital light processing printed hydrogel-composite osteochondral scaffold. Ann Biomed Eng. 2024;52(8):2162-2177. doi: 10.1007/s10439-024-03516-x
59. Golebiowska A, Nukavarapu SP. Bio-inspired zonal-structured matrices for bone-cartilage interface engineering. Biofabrication. 2022;14(2):025016. doi: 10.1088/1758-5090/ac52e1
60. Sun Y, Wu Q, Zhang Y, Dai K, Wei Y. 3D-bioprinted gradient-structured scaffold generates anisotropic cartilage with vascularization by pore-size-dependent activation of HIF1α/FAK signaling axis. Nanomedicine. 2021; 37:102426. doi: 10.1016/j.nano.2021.102426
61. Gu Y, Zou Y, Huang Y, et al. 3D-printed biomimetic scaffolds with precisely controlled and tunable structures guide cell migration and promote regeneration of osteochondral defect. Biofabrication. 2023;16(1):015003. doi: 10.1088/1758-5090/ad0071
62. Kilian D, Cometta S, Bernhardt A, et al. Core-shell bioprinting as a strategy to apply differentiation factors in a spatially defined manner inside osteochondral tissue substitutes. Biofabrication. 2022;14(1):014108. doi: 10.1088/1758-5090/ac457b
63. Zhang Y, Li D, Liu Y, et al. 3D-bioprinted anisotropic bicellular living hydrogels boost osteochondral regeneration via reconstruction of cartilage-bone interface. Innovation (Camb). 2024;5(1):100542. doi: 10.1016/j.xinn.2023.100542
64. Maherani M, Eslami H, Poursamar SA, Ansari M. A modular approach to 3D-printed bilayer composite scaffolds for osteochondral tissue engineering. J Mater Sci Mater Med. 2024;35(1):62. doi: 10.1007/s10856-024-06824-9
65. O’Shea DG, Hodgkinson T, Curtin CM, O’Brien FJ. An injectable and 3D printable pro-chondrogenic hyaluronic acid and collagen type II composite hydrogel for the repair of articular cartilage defects. Biofabrication. 2023;16(1):015007. doi: 10.1088/1758-5090/ad047a
66. Zineh BR, Roshangar L, Meshgi S, Shabgard M. 3D printing of alginate/thymoquinone/halloysite nanotube bio-scaffolds for cartilage repairs: experimental and numerical study. Med Biol Eng Comput. 2022;60(11):3069-3080. doi: 10.1007/s11517-022-02654-5
67. Naranda J, Bračič M, Vogrin M, Maver U. Recent advancements in 3d printing of polysaccharide hydrogels in cartilage tissue engineering. Materials (Basel). 2021;14(14):3977. doi: 10.3390/ma14143977
68. Majumder N, Roy C, Doenges L, Martin I, Barbero A, Ghosh S. Covalent conjugation of small molecule inhibitors and growth factors to a silk fibroin-derived bioink to develop phenotypically stable 3D bioprinted cartilage. ACS Appl Mater Interfaces. 2024;16(8):9925-9943. doi: 10.1021/acsami.3c18903
69. Zhang W, Lian Q, Li D, et al. Cartilage repair and subchondral bone migration using 3D printing osteochondral composites: a one-year-period study in rabbit trochlea. Biomed Res Int. 2014;2014:746138. doi: 10.1155/2014/746138
70. Golebiowska AA, Nukavarapu SP. Bio-inspired zonal-structured matrices for bone-cartilage interface engineering. Biofabrication. 2022;14(2):025016. doi: 10.1088/1758-5090/ac5413
71. Jiang G, Li S, Yu K, et al. A 3D-printed PRP-GelMA hydrogel promotes osteochondral regeneration through M2 macrophage polarization in a rabbit model. Acta Biomater. 2021;128:150-162. doi: 10.1016/j.actbio.2021.04.010
72. Parisi C, Salvatore L, Veschini L, et al. Biomimetic gradient scaffold of collagen-hydroxyapatite for osteochondral regeneration. J Tissue Eng. 2020;11:2041731419896068. doi: 10.1177/2041731419896068
73. Sa MW, Nguyen BB, Moriarty RA, Kamalitdinov T, Fisher JP, Kim JY. Fabrication and evaluation of 3D printed BCP scaffolds reinforced with ZrO(2) for bone tissue applications. Biotechnol Bioeng. 2018;115(4):989-999. doi: 10.1002/bit.26514
74. Liu L, Yu F, Chen L, Xia L, Wu C, Fang B. Lithium-containing biomaterials stimulate cartilage repair through bone marrow stromal cells-derived exosomal miR-455-3p and Histone H3 acetylation. Adv Healthc Mater. 2023;12(11):e2202390. doi: 10.1002/adhm.202202390
75. Zheng J, Mao X, Ling J, Chen C, Zhang W. Role of magnesium transporter subtype 1 (MagT1) in the osteogenic differentiation of rat bone marrow stem cells. Biol Trace Elem Res. 2016;171(1):131-137. doi: 10.1007/s12011-015-0459-4
76. Wang X, Gao L, Han Y, et al. Silicon-enhanced adipogenesis and angiogenesis for vascularized adipose tissue engineering. Adv Sci (Weinh). 2018;5(11):1800776. doi: 10.1002/advs.201800776
77. Rahaman MN, Day DE, Bal BS, et al. Bioactive glass in tissue engineering. Acta Biomater. 2011;7(6):2355-2373. doi: 10.1016/j.actbio.2011.03.016
78. Morgan EF, Salisbury Palomares KT, Gleason RE, et al. Correlations between local strains and tissue phenotypes in an experimental model of skeletal healing. J Biomech. 2010;43(12):2418-2424. doi: 10.1016/j.jbiomech.2010.04.019
79. Claes L, Eckert-Hübner K, Augat P. The effect of mechanical stability on local vascularization and tissue differentiation in callus healing. J Orthop Res. 2002;20(5):1099-1105. doi: 10.1016/s0736-0266(02)00044-x
80. Chen C, Xie J, Deng L, Yang L. Substrate stiffness together with soluble factors affects chondrocyte mechanoresponses. ACS Appl Mater Interfaces. 2014;6(18):16106-16116. doi: 10.1021/am504135b
81. Yang Y, Feng Y, Qu R, et al. Synthesis of aligned porous polyethylene glycol/silk fibroin/hydroxyapatite scaffolds for osteoinduction in bone tissue engineering. Stem Cell Res Ther. 2020;11(1):522. doi: 10.1186/s13287-020-02024-8
82. Cao B, Li J, Wang X, et al. Mechanosensitive miR-99b mediates the regulatory effect of matrix stiffness on bone marrow mesenchymal stem cell fate both in vitro and in vivo. APL Bioeng. 2023;7(1):016106. doi: 10.1063/5.0131125
83. Lai Q, Li B, Chen L, Zhou Y, Bao H, Li H. Substrate stiffness regulates the proliferation and inflammation of chondrocytes and macrophages through exosomes. Acta Biomater. 2025;192:77-89. doi: 10.1016/j.actbio.2024.12.021
84. Tortorici M, Petersen A, Ehrhart K, Duda GN, Checa S. Scaffold-dependent mechanical and architectural cues guide osteochondral defect healing in silico. Front Bioeng Biotechnol. 2021;9:642217. doi: 10.3389/fbioe.2021.642217
85. Radhakrishnan J, Manigandan A, Chinnaswamy P, Subramanian A, Sethuraman S. Gradient nano-engineered in situ forming composite hydrogel for osteochondral regeneration. Biomaterials. 2018;162:82-98. doi: 10.1016/j.biomaterials.2018.01.056
86. Pattnaik A, Sanket AS, Pradhan S, et al. Designing of gradient scaffolds and their applications in tissue regeneration. Biomaterials. 2023;296:122078. doi: doi: 10.1016/j.biomaterials.2023.122078
87. Zhang W, Chen J, Tao J, et al. The use of type 1 collagen scaffold containing stromal cell-derived factor-1 to create a matrix environment conducive to partial-thickness cartilage defects repair. Biomaterials. 2013;34(3):713-723. doi: 10.1016/j.biomaterials.2012.10.027
88. Hayashi K, Shimabukuro M, Kishida R, Tsuchiya A, Ishikawa K. Honeycomb scaffolds capable of achieving barrier membrane-free guided bone regeneration. Mater Adv. 2021;2(23):7638-7649. doi: 10.1039/D1MA00698C
89. Zhao Y, Liang Y, Ding S, Zhang K, Mao HQ, Yang Y. Application of conductive PPy/SF composite scaffold and electrical stimulation for neural tissue engineering. Biomaterials. 2020;255:120164. doi: 10.1016/j.biomaterials.2020.120164
90. He J, Sun C, Gu Z, et al. Morphology, migration, and transcriptome analysis of schwann cell culture on butterfly wings with different surface architectures. ACS Nano. 2018;12(10):9660-9668. doi: 10.1021/acsnano.8b00552
91. Zhang J, Wu Y, Thote T, Lee EH, Ge Z, Yang Z. The influence of scaffold microstructure on chondrogenic differentiation of mesenchymal stem cells. Biomed Mater. 2014;9(3):035011. doi: 10.1088/1748-6041/9/3/035011
92. DeLise AM, Fischer L, Tuan RS. Cellular interactions and signaling in cartilage development. Osteoarthritis Cartilage. 2000;8(5):309-334. doi: 10.1053/joca.1999.0306
93. Li S, Tallia F, Mohammed AA, Stevens MM, Jones JR. Scaffold channel size influences stem cell differentiation pathway in 3-D printed silica hybrid scaffolds for cartilage regeneration. Biomater Sci. 2020;8(16):4458-4466. doi: 10.1039/c9bm01829h
94. Zanetti NC, Solursh M. Induction of chondrogenesis in limb mesenchymal cultures by disruption of the actin cytoskeleton. J Cell Biol. 1984;99(1 Pt 1):115-123. doi: 10.1083/jcb.99.1.115
95. Vanden Berg-Foels WS. In situ tissue regeneration: chemoattractants for endogenous stem cell recruitment. Tissue Eng Part B Rev. 2014;20(1):28-39.doi: 10.1089/ten.TEB.2013.0100
96. Salgado AJ, Coutinho OP, Reis RL. Bone tissue engineering: state of the art and future trends. Macromol Biosci. 2004;4(8):743-765. doi: 10.1002/mabi.200400026
97. Zhang X, Chen X, Hong H, Hu R, Liu J, Liu C. Decellularized extracellular matrix scaffolds: recent trends and emerging strategies in tissue engineering. Bioact Mater. 2022;10:15-31. doi: 10.1016/j.bioactmat.2021.09.014
98. Jang J, Kim TG, Kim BS, Kim SW, Kwon SM, Cho DW. Tailoring mechanical properties of decellularized extracellular matrix bioink by vitamin B2-induced photo-crosslinking. Acta Biomater. 2016;33:88-95. doi: 10.1016/j.actbio.2016.01.013
99. Zhang X, Liu Y, Luo C, et al. Crosslinker-free silk/ decellularized extracellular matrix porous bioink for 3D bioprinting-based cartilage tissue engineering. Mater Sci Eng C Mater Biol Appl. 2021;118:111388. doi: 10.1016/j.msec.2020.111388
100. Joyce M, Hodgkinson T, Lemoine M, González-Vázquez A, Kelly DJ, O’Brien FJ. Development of a 3D-printed bioabsorbable composite scaffold with mechanical properties suitable for treating large, load-bearingarticular cartilage defects. Eur Cell Mater. 2023;45:158-172. doi: 10.22203/eCM.v045a11
101. Johnson K, Zhu S, Tremblay MS, et al. A stem cell-based approach to cartilage repair. Science. 2012;336(6082):717-721. doi: 10.1126/science.1215157
102. Stefani RM, Lee AJ, Tan AR, et al. Sustained low-dose dexamethasone delivery via a PLGA microsphere-embedded agarose implant for enhanced osteochondral repair. Acta Biomaterialia. 2020;102:326-340. doi: doi: 10.1016/j.actbio.2019.11.052
103. Brito Barrera YA, Husteden C, Alherz J, Fuhrmann B, Wölk C, Groth T. Extracellular matrix-inspired surface coatings functionalized with dexamethasone-loaded liposomes to induce osteo- and chondrogenic differentiation of multipotent stem cells. Mater Sci Eng C Mater Biol Appl. 2021;131:112516. doi: 10.1016/j.msec.2021.112516
104. Yan X, Chen YR, Song YF, et al. Scaffold-based gene therapeutics for osteochondral tissue engineering. Front Pharmacol. 2019;10:1534. doi: 10.3389/fphar.2019.01534
105. An C, Cheng Y, Yuan Q, Li J. IGF-1 and BMP-2 induces differentiation of adipose-derived mesenchymal stem cells into chondrocytes-like cells. Ann Biomed Eng. 2010;38(4):1647-1654. doi: 10.1007/s10439-009-9892-x
106. Tao K, Frisch J, Rey-Rico A, et al. Co-overexpression of TGF-β and SOX9 via rAAV gene transfer modulates the metabolic and chondrogenic activities of human bone marrow-derived mesenchymal stem cells. Stem Cell Res Ther. 2016;7:20. doi: 10.1186/s13287-016-0280-9
107. Lee JM, Im GI. SOX trio-co-transduced adipose stem cells in fibrin gel to enhance cartilage repair and delay the progression of osteoarthritis in the rat. Biomaterials. 2012;33(7):2016-2024. doi: 10.1016/j.biomaterials.2011.11.050
108. Vermeij EA, Broeren MG, Bennink MB, et al. Disease-regulated local IL-10 gene therapy diminishes synovitis and cartilage proteoglycan depletion in experimental arthritis. Ann Rheum Dis. 2015;74(11):2084-2091. doi: 10.1136/annrheumdis-2014-205223
109. Kay JD, Gouze E, Oligino TJ, et al. Intra-articular gene delivery and expression of interleukin-1Ra mediated by self-complementary adeno-associated virus. J Gene Med. 2009;11(7):605-614. doi: 10.1002/jgm.1334
110. Bellavia D, Veronesi F, Carina V, et al. Gene therapy for chondral and osteochondral regeneration: is the future now? Cell Mol Life Sci. 2018;75(4):649-667. doi: 10.1007/s00018-017-2637-3
111. Lu H, Wei J, Liu K, et al. Radical-scavenging and subchondral bone-regenerating nanomedicine for osteoarthritis treatment. ACS Nano. 2023;17(6):6131-6146. doi: 10.1021/acsnano.3c01789
112. Chen Y, Huang H, Zhong W, Li L, Lu Y, Si HB. miR- 140-5p protects cartilage progenitor/stem cells from fate changes in knee osteoarthritis. Int Immunopharmacol. 2023; 114:109576. doi: 10.1016/j.intimp.2022.109576
113. Xing H, Zhang Z, Mao Q, et al. Injectable exosome-functionalized extracellular matrix hydrogel for metabolism balance and pyroptosis regulation in intervertebral disc degeneration. J Nanobiotechnol. 2021;19(1):264. doi: 10.1186/s12951-021-00991-5
114. Zhu W, Wang H, Feng B, et al. Self-healing hyaluronic acid-based hydrogel with miRNA140-5p loaded MON-PEI nanoparticles for chondrocyte regeneration: Schiff base self-assembly approach. Adv Sci (Weinh). 2025;12(1):e2406479. doi: 10.1002/advs.202406479
115. Tuan RS, Chen AF, Klatt BA. Cartilage regeneration. J Am Acad Orthop Surg. 2013;21(5):303-311. doi: 10.5435/jaaos-21-05-303
116. Wang LT, Ting CH, Yen ML, et al. Human mesenchymal stem cells (MSCs) for treatment towards immune- and inflammation-mediated diseases: review of current clinical trials. J Biomed Sci. 2016;23(1):76. doi: 10.1186/s12929-016-0289-5
117. Bush CJ, Grant JA, Krych AJ, Bedi A. The role of mesenchymal stromal cells in the management of knee chondral defects. J Bone Joint Surg Am. 2022;104(3):284-292.doi: 10.2106/jbjs.20.01800
118. Armiento AR, Alini M, Stoddart MJ. Articular fibrocartilage - why does hyaline cartilage fail to repair? Adv Drug Deliv Rev. 2019;146:289-305. doi: 10.1016/j.addr.2018.12.015
119. Knutsen G, Engebretsen L, Ludvigsen TC, et al. Autologous chondrocyte implantation compared with microfracture in the knee. A randomized trial. J Bone Joint Surg Am. 2004;86(3):455-464. doi: 10.2106/00004623-200403000-00001
120. Zhen G, Wen C, Jia X, et al. Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis. Nat Med. 2013;19(6):704-712. doi: 10.1038/nm.3143
121. Lam J, Lu S, Kasper FK, Mikos AG. Strategies for controlled delivery of biologics for cartilage repair. Adv Drug Deliv Rev. 2015;84:123-134. doi: doi: 10.1016/j.addr.2014.06.006
122. Möller T, Amoroso M, Hägg D, et al. In vivo chondrogenesis in 3d bioprinted human cell-laden hydrogel constructs. Plast Reconstr Surg Glob Open. 2017;5(2):e1227. doi: 10.1097/gox.0000000000001227
123. Wu H, Wang X, Wang G, et al. Advancing scaffold-assisted modality for in situ osteochondral regeneration: a shift from biodegradable to bioadaptable. Adv Mater. 2024;36(47):e2407040. doi: 10.1002/adma.202407040
124. Karageorgiou V, Kaplan D. Porosity of 3D biomaterial scaffolds and osteogenesis. Biomaterials. 2005;26(27): 5474-5491. doi: 10.1016/j.biomaterials.2005.02.002
125. Brauer DS. Bioactive glasses—structure and properties. Angew Chem Int Ed Engl. 2015;54(14):4160-4181. doi: 10.1002/anie.201405310
126. Bejarano J, Boccaccini AR, Covarrubias C, Palza H. Effect of Cu- and Zn-doped bioactive glasses on the in vitro bioactivity, mechanical and degradation behavior of biodegradable PDLLA scaffolds. Materials (Basel). 2020;13(13):2908. doi: 10.3390/ma13132908
127. Heiden M, Nauman E, Stanciu L. Bioresorbable Fe–Mn and Fe–Mn–HA materials for orthopedic implantation: enhancing degradation through porosity control. Adv Healthc Mater. 2017;6(13):1700120. doi: doi: 10.1002/adhm.201700120
128. Kim JA, Lim J, Naren R, Yun HS, Park EK. Effect of the biodegradation rate controlled by pore structures in magnesium phosphate ceramic scaffolds on bone tissue regeneration in vivo. Acta Biomater. 2016;44:155-167. doi: 10.1016/j.actbio.2016.08.039
129. Qu Z, Liu L, Deng Y, et al. Relationship between biodegradation rate and grain size itself excluding other structural factors caused by alloying additions and deformation processing for pure Mg. Materials (Basel). 2022;15(15):5295. doi: 10.3390/ma15155295
130. Hu Q, Ecker M. Overview of MMP-13 as a promising target for the treatment of osteoarthritis. Int J Mol Sci. 2021;22(4):1742. doi: 10.3390/ijms22041742
131. Choe R, Devoy E, Jabari E, Packer JD, Fisher JP. Biomechanical aspects of osteochondral regeneration: implications and strategies for three-dimensional bioprinting. Tissue Eng Part B Rev. 2022;28(4):766-788. doi: 10.1089/ten.TEB.2021.0101
132. Knudson W, Casey B, Nishida Y, Eger W, Kuettner KE, Knudson CB. Hyaluronan oligosaccharides perturb cartilage matrix homeostasis and induce chondrocytic chondrolysis. Arthritis Rheum. 2000;43(5):1165-1174. doi: 10.1002/1529-0131(200005)43:5<1165::Aid-anr27> 3.0.Co;2-h
133. Yildirim N, Amanzhanova A, Kulzhanova G, Mukasheva F, Erisken C. Osteochondral interface: regenerative engineering and challenges. ACS Biomater Sci Eng. 2023;9(3):1205-1223. doi: 10.1021/acsbiomaterials.2c01321
134. Kamaraj M, Roopavath UK, Giri PS, Ponnusamy NK, Rath SN. Modulation of 3D printed calcium-deficient apatite constructs with varying mn concentrations for osteochondral regeneration via endochondral differentiation. ACS Appl Mater Interfaces. 2022;14(20):23245-23259. doi: 10.1021/acsami.2c05110
135. Liuyun J, Lixin J, Chengdong X, Lijuan X, Ye L. Effect of l-lysine-assisted surface grafting for nano-hydroxyapatite on mechanical properties and in vitro bioactivity of poly(lactic acid-co-glycolic acid). J Biomater Appl. 2016;30(6):750-758. doi: 10.1177/0885328215584491
136. Nedrelow DS, Townsend JM, Detamore MS. Osteochondral regeneration with anatomical scaffold 3D-printing-design considerations for interface integration. J Biomed Mater Res A. 2025;113(1):e37804. doi: 10.1002/jbm.a.37804
137. Brown WE, Huang BJ, Hu JC, Athanasiou KA. Engineering large, anatomically shaped osteochondral constructs with robust interfacial shear properties. NPJ Regen Med. 2021;6(1):42. doi: 10.1038/s41536-021-00152-0
138. Feng P, He J, Peng S, et al. Characterizations and interfacial reinforcement mechanisms of multicomponent biopolymer based scaffold. Mater Sci Eng C Mater Biol Appl. 2019;100:809-825. doi: 10.1016/j.msec.2019.03.030
139. Wang L, Zhao L, Detamore MS. Human umbilical cord mesenchymal stromal cells in a sandwich approach for osteochondral tissue engineering. J Tissue Eng Regen Med. 2011;5(9):712-721. doi: 10.1002/term.370
140. Li S, Liu C, Zhang Y, et al. Continuous 3D printing of biomimetic beetle mandible structure with long bundles of aramid fiber composites. Biomimetics (Basel). 2023;8(3):283. doi: 10.3390/biomimetics8030283
141. Yodmuang S, Guo H, Brial C, et al. Effect of interface mechanical discontinuities on scaffold-cartilage integration. J Orthop Res. 2019;37(4):845-854. doi: 10.1002/jor.24238
142. Zhao R, Han F, Yu Q, et al. A multifunctional scaffold that promotes the scaffold-tissue interface integration and rescues the ROS microenvironment for repair of annulus fibrosus defects. Bioact Mater. 2024;41:257-270. doi: 10.1016/j.bioactmat.2024.03.007
143. Torres-Claramunt R, Martínez-Díaz S, Sánchez-Soler JF, et al. Fibronectin-coated polyurethane meniscal scaffolding supplemented with MSCs improves scaffold integration and proteoglycan production in a rabbit model. Knee Surg Sports Traumatol Arthrosc. 2023;31(11):5104-5110. doi: 10.1007/s00167-023-07562-1
144. Chung JY, Song M, Ha CW, Kim JA, Lee CH, Park YB. Comparison of articular cartilage repair with different hydrogel-human umbilical cord blood-derived mesenchymal stem cell composites in a rat model. Stem Cell Res Ther. 2014;5(2):39. doi: 10.1186/scrt427
145. Romito L, Ameer GA. Mechanical interlocking of engineered cartilage to an underlying polymeric substrate: towards a biohybrid tissue equivalent. Ann Biomed Eng. 2006;34(5):737-747. doi: 10.1007/s10439-006-9089-5
146. Scotti C, Wirz D, Wolf F, et al. Engineering human cell-based, functionally integrated osteochondral grafts by biological bonding of engineered cartilage tissues to bony scaffolds. Biomaterials. 2010;31(8):2252-2259. doi: 10.1016/j.biomaterials.2009.11.110
147. Ege D, Hasirci V. Is 3D printing promising for osteochondral tissue regeneration? ACS Appl Bio Mater. 2023;6(4):1431-1444. doi: 10.1021/acsabm.3c00093
148. Jammalamadaka U, Tappa K. Recent advances in biomaterials for 3d printing and tissue engineering. J Funct Biomater. 2018;9(1):22. doi: 10.3390/jfb9010022
149. Steinmetz NJ, Aisenbrey EA, Westbrook KK, Qi HJ, Bryant SJ. Mechanical loading regulates human MSC differentiation in a multi-layer hydrogel for osteochondral tissue engineering. Acta Biomater. 2015;21:142-153. doi: 10.1016/j.actbio.2015.04.015
150. Kilian D, Ahlfeld T, Akkineni AR, Bernhardt A, Gelinsky M, Lode A. 3D Bioprinting of osteochondral tissue substitutes - in vitro-chondrogenesis in multi-layered mineralized constructs. Sci Rep. 2020;10(1):8277. doi: 10.1038/s41598-020-65050-9
151. Gong L, Li J, Zhang J, et al. An interleukin-4-loaded bi-layer 3D printed scaffold promotes osteochondral regeneration. Acta Biomater. 2020;117:246-260. doi: 10.1016/j.actbio.2020.09.039
152. Senior JJ, Cooke ME, Grover LM, Smith AM. Fabrication of complex hydrogel structures using suspended layer additive manufacturing (SLAM). Adv Funct Mater. 2019;29(49):1904845. doi: doi: 10.1002/adfm.201904845
153. Uzcategui AC, Muralidharan A, Ferguson VL, Bryant SJ, McLeod RR. Understanding and improving mechanical properties in 3D printed parts using a dual-cure acrylate-based resin for stereolithography. Adv Eng Mater. 2018;20(12);1800876. doi: 10.1002/adem.201800876
154. Li X, Liu B, Pei B, et al. Inkjet bioprinting of biomaterials. Chem Rev. 2020;120(19):10793-10833. doi: 10.1021/acs.chemrev.0c00008
155. Dufour A, Gallostra XB, O’Keeffe C, et al. Integrating melt electrowriting and inkjet bioprinting for engineering structurally organized articular cartilage. Biomaterials. 2022;283:121405. doi: 10.1016/j.biomaterials.2022.121405
156. Li Q, Xu S, Feng Q, et al. 3D printed silk-gelatin hydrogel scaffold with different porous structure and cell seeding strategy for cartilage regeneration. Bioact Mater. 2021;6(10):3396-3410. doi: 10.1016/j.bioactmat.2021.03.013
157. Ahn SH, Lee J, Park SA, Kim WD. Three-dimensional bio-printing equipment technologies for tissue engineering and regenerative medicine. Tissue Eng Regen Med. 2016;13(6):663-676. doi: 10.1007/s13770-016-0148-1
158. Della Bona A, Cantelli V, Britto VT, Collares KF, Stansbury JW. 3D printing restorative materials using a stereolithographic technique: a systematic review. Dent Mater. 2021;37(2):336-350. doi: 10.1016/j.dental.2020.11.030
159. Jeong M, Radomski K, Lopez D, Liu JT, Lee JD, Lee SJ. Materials and applications of 3D printing technology in dentistry: an overview. Dent J (Basel). 2023;12(1):1. doi: 10.3390/dj12010001
160. Wang Y, Ling C, Chen J, et al. 3D-printed composite scaffold with gradient structure and programmed biomolecule delivery to guide stem cell behavior for osteochondral regeneration. Biomater Adv. 2022;140:213067. doi: 10.1016/j.bioadv.2022.213067
161. Cailleaux S, Sanchez-Ballester NM, Gueche YA, Bataille B, Soulairol I. Fused Deposition Modeling (FDM), the new asset for the production of tailored medicines. J Control Release. 2021;330:821-841. doi: 10.1016/j.jconrel.2020.10.056
162. Jia W, Liu Z, Sun L, et al. A multicrosslinked network composite hydrogel scaffold based on DLP photocuring printing for nasal cartilage repair. Biotechnol Bioeng. 2024;121(9):2752-2766. doi: 10.1002/bit.28769
163. Choe R, Devoy E, Kuzemchak B, et al. Computational investigation of interface printing patterns within 3D printed multilayered scaffolds for osteochondral tissue engineering. Biofabrication. 2022;14(2):025015. doi: 10.1088/1758-5090/ac5220
164. Tamaddon M, Liu C. Enhancing biological and biomechanical fixation of osteochondral scaffold: a grand challenge. Adv Exp Med Biol. 2018;1059:255-298. doi: 10.1007/978-3-319-76735-2_12
165. Tamaddon M, Czernuszka J. The need for hierarchical scaffolds in bone tissue engineering. Hard Tissue. 2013;2:37. doi: 10.13172/2050-2303-2-4-773
166. Colosi C, Shin SR, Manoharan V, et al. Microfluidic bioprinting of heterogeneous 3D tissue constructs using low-viscosity bioink. Adv Mater. 2016;28(4):677-684. doi: 10.1002/adma.201503310
167. García-Fernández L. Osteochondral angiogenesis and promoted vascularization: new therapeutic target. Adv Exp Med Biol. 2018;1059:315-330. doi: 10.1007/978-3-319-76735-2_14
168. Sachlos E, Czernuszka JT. Making tissue engineering scaffolds work. Review: the application of solid freeform fabrication technology to the production of tissue engineering scaffolds. Eur Cell Mater. 2003;5:29-39; discussion 39-40. doi: 10.22203/ecm.v005a03
169. Perets A, Baruch Y, Weisbuch F, Shoshany G, Neufeld G, Cohen S. Enhancing the vascularization of three-dimensional porous alginate scaffolds by incorporating controlled release basic fibroblast growth factor microspheres. J Biomed Mater Res A. 2003;65(4):489-497. doi: 10.1002/jbm.a.10542
170. Li B, Wang H, Qiu G, Su X, Wu Z. Synergistic effects of vascular endothelial growth factor on bone morphogenetic proteins induced bone formation in vivo: influencing factors and future research directions. Biomed Res Int. 2016;2016:2869572. doi: 10.1155/2016/2869572
171. Centola M, Abbruzzese F, Scotti C, et al. Scaffold-based delivery of a clinically relevant anti-angiogenic drug promotes the formation of in vivo stable cartilage. Tissue Eng Part A. 2013;19(17-18):1960-1971. doi: 10.1089/ten.TEA.2012.0455
172. Firsching-Hauck A, Nickel P, Yahya C, et al. Angiostatic effects of suramin analogs in vitro. Anticancer Drugs. 2000;11(2):69-77. doi: 10.1097/00001813-200002000-00002
173. Qin C, Zhang H, Chen L, et al. Cell-laden scaffolds for vascular-innervated bone regeneration. Adv Healthc Mater. 2023;12(13):e2201923. doi: 10.1002/adhm.202201923
174. Liang X, Xie L, Zhang Q, et al. Gelatin methacryloyl-alginate core-shell microcapsules as efficient delivery platforms for prevascularized microtissues in endodontic regeneration. Acta Biomater. 2022;144:242-257. doi: 10.1016/j.actbio.2022.03.045
175. Lu X, Dai S, Huang B, et al. Exosomes loaded a smart bilayer-hydrogel scaffold with ROS-scavenging and macrophage-reprogramming properties for repairing cartilage defect. Bioact Mater. 2024;38:137-153. doi: 10.1016/j.bioactmat.2024.04.017
176. Xu M, Su T, Jin X, et al. Inflammation-mediated matrix remodeling of extracellular matrix-mimicking biomaterials in tissue engineering and regenerative medicine. Acta Biomater. 2022;151:106-117. doi: doi: 10.1016/j.actbio.2022.08.015
177. Shu C, Qin C, Chen L, et al. Metal-organic framework functionalized bioceramic scaffolds with antioxidative activity for enhanced osteochondral regeneration. Adv Sci (Weinh). 2023;10(13):e2206875. doi: 10.1002/advs.202206875
178. Del Rio D, Stewart AJ, Pellegrini N. A review of recent studies on malondialdehyde as toxic molecule and biological marker of oxidative stress. Nutr Metab Cardiovasc Dis. 2005;15(4):316-328. doi: 10.1016/j.numecd.2005.05.003
179. Gu T, Zhang Z, Liu J, et al. Chlorogenic acid alleviates LPS-induced inflammation and oxidative stress by modulating CD36/AMPK/PGC-1α in RAW264.7 macrophages. Int J Mol Sci. 2023;24(17):13516. doi: 10.3390/ijms241713516
180. Vapniarsky N, Simpson DL, Arzi B, et al. Histological, immunological, and genetic analysis of feline chronic gingivostomatitis. Front Vet Sci. 2020;7:310. doi: 10.3389/fvets.2020.00310
181. Mata R, Yao Y, Cao W, et al. The dynamic inflammatory tissue microenvironment: signality and disease therapy by biomaterials. Research (Wash D C). 2021; 2021:4189516. doi: 10.34133/2021/4189516
182. Li S, Niu D, Fang H, et al. Tissue adhesive, ROS scavenging and injectable PRP-based ‘plasticine’ for promoting cartilage repair. Regen Biomater. 2024;11:rbad104. doi: 10.1093/rb/rbad104
183. Liu D, Lu G, Shi B, et al. ROS-scavenging hydrogels synergize with neural stem cells to enhance spinal cord injury repair via regulating microenvironment and facilitating nerve regeneration. Adv Healthc Mater. 2023;12(18):e2300123. doi: 10.1002/adhm.202300123
184. Sun H, Xu J, Wang Y, et al. Bone microenvironment regulative hydrogels with ROS scavenging and prolonged oxygen-generating for enhancing bone repair. Bioact Mater. 2023;24:477-496. doi: 10.1016/j.bioactmat.2022.12.021
185. Hu C, Huang R, Xia J, et al. A nanozyme-functionalized bilayer hydrogel scaffold for modulating the inflammatory microenvironment to promote osteochondral regeneration. J Nanobiotechnol. 2024;22(1):445. doi: 10.1186/s12951-024-02723-x
186. Zhao Z, Xia X, Liu J, et al. Cartilage-inspired self-assembly glycopeptide hydrogels for cartilage regeneration via ROS scavenging. Bioact Mater. 2024;32:319-332. doi: 10.1016/j.bioactmat.2023.10.013
187. Liu Z, Wang T, Zhang L, et al. Metal-phenolic networks-reinforced extracellular matrix scaffold for bone regeneration via combining radical-scavenging and photo-responsive regulation of microenvironment. Adv Healthc Mater. 2024;13(15):e2304158. doi: 10.1002/adhm.202304158
188. Zhao LL, Luo JJ, Cui J, et al. Tannic acid-modified decellularized tendon scaffold with antioxidant and anti-inflammatory activities for tendon regeneration. ACS Appl Mater Interfaces. 2024;16(13):15879-15892. doi: 10.1021/acsami.3c19019
189. Xue H, Zhang Z, Lin Z, et al. Enhanced tissue regeneration through immunomodulation of angiogenesis and osteogenesis with a multifaceted nanohybrid modified bioactive scaffold. Bioact Mater. 2022;18:552-568. doi: 10.1016/j.bioactmat.2022.05.023
190. Deng C, Zhou Q, Zhang M, et al. Bioceramic Scaffolds with Antioxidative Functions for ROS scavenging and osteochondral regeneration. Adv Sci (Weinh). 2022;9(12):e2105727. doi: 10.1002/advs.202105727
191. Zhou T, Xiong H, Wang SQ, et al. An injectable hydrogel dotted with dexamethasone acetate-encapsulated reactive oxygen species-scavenging micelles for combinatorial therapy of osteoarthritis. Materials Today Nano. 2022;17:100164. doi: 10.1016/j.mtnano.2021.100164
192. Pan Y, Cao S, Terker AS, et al. Myeloid cyclooxygenase-2/ prostaglandin E2/E-type prostanoid receptor 4 promotes transcription factor MafB-dependent inflammatory resolution in acute kidney injury. Kidney Int. 2022;101(1):79-91. doi: 10.1016/j.kint.2021.09.033
193. da Silva Morais A, Oliveira JM, Reis RL. Small animal models. Adv Exp Med Biol. 2018;1059:423-439. doi: 10.1007/978-3-319-76735-2_19
194. Liu TP, Ha P, Xiao CY, et al. Updates on mesenchymal stem cell therapies for articular cartilage regeneration in large animal models. Front Cell Dev Biol. 2022;10:982199. doi: 10.3389/fcell.2022.982199
195. McIlwraith CW, Frisbie DD, Kawcak CE, Fuller CJ, Hurtig M, Cruz A. The OARSI histopathology initiative - recommendations for histological assessments of osteoarthritis in the horse. Osteoarthritis Cartilage. 2010;18(Suppl 3):S93-105. doi: 10.1016/j.joca.2010.05.031
196. McCoy AM. Animal models of osteoarthritis: comparisons and key considerations. Vet Pathol. 2015;52(5):803-818. doi: 10.1177/0300985815588611
197. Proffen BL, McElfresh M, Fleming BC, Murray MM. A comparative anatomical study of the human knee and six animal species. Knee. 2012;19(4):493-499. doi: 10.1016/j.knee.2011.07.005