Advanced 3D-printed microneedle patches for smart drug delivery in wound care

¹ Department of Information Convergence Engineering, School of Biomedical Convergence Engineering, Pusan National University, Yangsan, Republic of Korea

² Medical Research Institute, Pusan National University, Yangsan, Republic of Korea

³ Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea

IJB, 8514 https://doi.org/10.36922/ijb.8514

Submitted: 13 January 2025 | Accepted: 12 February 2025 | Published: 19 February 2025

(This article belongs to the Special Issue Intelligent 3D Bioprinting Strategies for Future Regenerative Medicine)

© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )

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Abstract

Microneedle (MN) patches have emerged as a promising drug delivery technology for wound healing treatments, offering several advantages over traditional administration methods, including minimal invasiveness, precise drug delivery, and minimal pain. This review explores the basic principles of MN patch technology, three-dimensional (3D) printing-assisted fabrication techniques, and the key considerations in designing effective MN patches for regenerative medicine. Moreover, the in vivo applications of the MN patches in wound healing, tissue regeneration, and drug delivery are discussed in detail. Finally, the challenges and future research directions of the MN patch technology are discussed, highlighting its potential to revolutionize personalized medication.

Keywords

Microneedle patch

3D printing

Responsive drug delivery

Bioinspired drug delivery

Wound healing

Funding

This work was supported by a two-year Research Grant of Pusan National University.

Conflict of interest

Byoung Soo Kim is the Guest Editor for this Special Issue, but did not in any way involve in the editorial and peer-review process conducted for this paper, directly or indirectly. The authors declare they have no competing interests.

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International Journal of Bioprinting, Electronic ISSN: 2424-8002 Print ISSN: 2424-7723, Published by AccScience Publishing