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REVIEW

Bioprinting of tumor immune microenvironment for immunotherapy

Sein Kim1 ,  Seokgyu Han2 ,  Jaehyun Lee3 ,  Chanyang Lee2 ,  Sungsu Park1,2*
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1 Department of Biomedical Engineering, Institute for Cross-disciplinary Studies (ICS), Sungkyunkwan University (SKKU), Suwon, Republic of Korea
2 Department of Mechanical Engineering, School of Mechanical Engineering, Sungkyunkwan University (SKKU), Suwon, Republic of Korea
3 Department of Bio-Integrated Science and Technology, College of Life Sciences, Sejong University, Seoul, Republic of Korea
IJB 2024, 10(5), 3988 https://doi.org/10.36922/ijb.3988
Submitted: 19 June 2024 | Accepted: 7 August 2024 | Published: 15 August 2024
© 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Accurately simulating the tumor immune microenvironment (TIME), which consists of a tumor, extracellular matrix (ECM), vascular network, and a variety of stromal and immune cells, is crucial for advancing and testing immunotherapies such as checkpoint inhibitors, chimeric antigen receptor-T (CAR-T) cells, and cancer vaccines. Traditional models, such as animal models, are limited by their differences from human immune environments. Bioprinting addresses these limitations by incorporating tumors, immune cells, and vascular cells within an ECM, thereby reflecting the complex interactions, including trafficking, between cancer and immune cells. These models provide better predictive accuracy for human immune responses, reducing translational failures and improving preclinical testing. While bioprinting methods for simulating the tumor microenvironment, where cancer cells form spheroids surrounded by blood vessels, are well reviewed, bioprinting methods for recapitulating the TIME are not as thoroughly explored. This review aims to fill this gap by exploring the development, application, and potential of bioprinted TIME models in enhancing the study and efficacy of immunotherapies, ultimately offering a more realistic and personalized approach to cancer treatment.

 

Keywords
Tumor
Immune microenvironment
Bioprinting
Immunotherapy
Efficacy
Funding
This work was supported by the National Research Foundation (NRF) of Korea grants funded by the Korea government (MSIT; No. RS-2023-00242443, RS-2023-00218543).
Conflict of interest
The authors declare they have no competing interests.
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International Journal of Bioprinting, Electronic ISSN: 2424-8002 Print ISSN: 2424-7723, Published by AccScience Publishing
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