Dear Colleagues,

The tumor microenvironment (TME) is a crucial factor in the advancement of cancer, impacting all phases from the beginning to the spread of cancer cells. The system is intricate and consists of immune cells, fibroblasts, endothelial cells, extracellular matrix, and different soluble components. The interaction between these components and cancer cells has a substantial impact on tumor behavior and treatment outcomes. Although there have been significant improvements in comprehending the TME, there are still important unresolved problems. Recent research has started to clarify the complex properties of the tumor microenvironment (TME), uncovering its influence on the proliferation of cancer cells, evasion of the immune system, formation of new blood vessels, and spread of cancer to other parts of the body.

Nevertheless, the tumor microenvironment (TME) presents a significant obstacle to the efficacy of existing cancer treatments. The condition is marked by low oxygen levels, increased acidity, raised pressure in the fluid between cells, and ingredients that weaken the immune system. These combined limitations impede the delivery and effectiveness of traditional treatments, emphasizing the necessity for creative methods to overcome these barriers.

Nanomedicine, the application of nanotechnology to medicinal interventions, has great potential for tackling the intricacies of the tumor microenvironment (TME). Engineered nanoparticles (NPs) have distinct physicochemical features that allow for precise drug distribution, improved therapeutic effectiveness, and decreased overall toxicity. Nevertheless, achieving effective implementation of NP-based therapeutics necessitates a comprehensive comprehension of the intricate interactions between NPs and the tumor microenvironment (TME).

The primary objective of this special issue is to expedite the progress of sophisticated nanomedicine platforms in order to efficiently tackle the obstacles posed by the tumor microenvironment (TME). The problem aims to improve drug delivery and therapeutic results in cancer treatments by combining innovative research and expert knowledge.

Dr. Mohd Ahmar Rauf

Dr. Mohammad Oves

Guest Editors