Dear Colleagues,

Age-related endothelial and smooth muscle cell dysfunctions play a pivotal role in the development of various cardiovascular and vascular disorders, including atherosclerosis, hypertension, and vascular stiffness. This research investigates innovative therapeutic approaches aimed at mitigating the deleterious effects of aging on vascular cells, thus addressing the root causes of age-related vascular diseases. The age-related decline in endothelial function, characterized by impaired nitric oxide production and increased oxidative stress, contributes to endothelial dysfunction. Similarly, aging-associated alterations in smooth muscle cells lead to vascular stiffness and maladaptive remodeling. To combat these dysfunctions, this study explores novel treatment modalities targeting both endothelial and smooth muscle cells. Cutting-edge strategies, such as gene therapy, nanomedicine, and regenerative medicine, offer promising avenues for rejuvenating aged vascular cells. Gene therapy techniques can enhance nitric oxide production, reduce oxidative stress, and promote vascular repair. Nanomedicine approaches enable precise drug delivery to target cells, minimizing off-target effects. Regenerative medicine techniques, including stem cell therapy and tissue engineering, hold the potential to replace or regenerate damaged vascular cells, restoring their youthful functionality.

This special issues will be highlights the urgent need for innovative treatments to combat age-related endothelial and smooth muscle cell dysfunctions and associated diseases. By targeting the cellular mechanisms underlying vascular aging, these novel therapies have the potential to revolutionize the management and prevention of age-linked cardiovascular and vascular disorders, ultimately improving the health and well-being of aging populations. This interdisciplinary research offers new hope for extending healthy aging and reducing the burden of age-related vascular diseases.

We look forward to receiving your original research articles and reviews.

Dr. Pazhanichamy Kalailingam

Dr. Suresh Veeraperumal

Guest Editors