AccScience Publishing / GPD / Volume 2 / Issue 1 / DOI: 10.36922/gpd.v2i1.235
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Autoimmune thyroid disease in narcolepsy: A case report

Chaofan Geng1 Zhenzhen Yang2 Hongju Zhang1,3*
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1 Henan University People’s Hospital, Henan Provincial People’s Hospital, Zhengzhou 450003, China
2 Fuwai Central China Cardiovascular Hospital, Henan Provincial People’s Hospital, Zhengzhou 450003, China
3 Zhengzhou University People’s Hospital, Henan Provincial People’s Hospital, Zhengzhou 450003, China
Submitted: 25 October 2022 | Accepted: 19 December 2022 | Published: 11 January 2023
© 2023 by the Author(s). Licensee AccScience Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( )

While the previous studies have discussed the association of narcolepsy with autoimmune diseases, autoimmune thyroid disease (IATD) has rarely been described in patients with narcolepsy. The association of narcolepsy with thyroid disease is intriguing for speculating the causal or coexisting autoimmune disorder. We report a case of narcolepsy Type 1 with IATD, presenting with excessive daytime sleepiness (EDS), cataplexy attacks, and unexplainable weight gain. Oral modafinil and sodium oxybate were used for treatment and prevention. During the 1-year follow-up, the patient’s EDS and cataplexy attacks improved. However, the patient developed hypothyroidism and was subsequently prescribed with thyroid replacement therapy.

Autoimmune thyroid disease
Case report
No funding was received in drafting this manuscript.

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Conflict of interest
The authors have no conflict of interest to declare.
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Gene & Protein in Disease, Electronic ISSN: 2811-003X Print ISSN: TBA, Published by AccScience Publishing