AccScience Publishing / GPD / Volume 2 / Issue 1 / DOI: 10.36922/gpd.v2i1.164
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Hydrogen sulfide donors and inhibitors in cancer research: A state-of-the-art review

Nazeer Hussain Khan1† Ebenezeri Erasto Ngowi2† Yan Li3 Saadullah Khattak1 Yingshuai Zhao4 Muhammad Shahid5 Ujala Zafar6 Irum Waheed7 Fatima Khan8 Razia Virk9 Istaqlal Hussain10 Jiebin Cao11 Hongxia Liu12 Zhihui Liu4* Dong-Dong Wu12* Xin-Ying Ji1*
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1 Henan International Joint Laboratory for Nuclear Protein Regulation, School of Basic Medical Sciences, Henan University, Kaifeng, Henan 475004, China
2 Department of Biological Sciences, Faculty of Science, Dar es Salaam University College of Education, Dar es Salaam 2329, Tanzania
3 Winship Cancer Institute of Emory University, 1365 Clifton Rd NE, Atlanta, GA 30322, USA
4 Department of General Practice, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, Henan, 450003, China
5 Department of Biological Sciences and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, Bangi, Selangor 43600, Malaysia
6 Department of Materials science and engineering, Soft Matter Hybrid Laboratory Sungkyunkwan University Natural Sciences Campus, Sungkyunkwan South Korea
7 Department of Biological sciences, University of Agriculture Faisalabad, Faisalabad Pakistan
8 Department of Chemistry, University of Sargodha, Sargodha Pakistan
9 Department of Bio-Sciences, University of Wah, Rawalpindi Pakistan
10 Department of Biological sciences, Government College University Faisalabad, Faisalabad Pakistan
11 Center for Disease Control and Prevention, Erqi District, Zhengzhou, Henan 450001, China
12 School of Stomatology, Henan University, Kaifeng, Henan 475004, China
Submitted: 30 July 2022 | Accepted: 2 November 2022 | Published: 15 December 2022
© 2022 by the Author(s). Licensee AccScience Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( )

Hydrogen sulfide (H2S), a gaseous biomolecule, is considered a key player in the regulation of various essential cellular events. Normal physiology is determined by the level of endogenous H2S. Any alterations (upregulation and downregulation) to the level of endogenous H2S may lead to illness, including the onset of tumorigenesis. Over the past two decades, extensive research on the role of H2S in cancer development has affirmed the potential pharmacological means to suppress cancer progression by either inhibiting H2S synthesis in cells or exposing exogenously supplied H2S donors to treat different cancers. Some H2S donors and inhibitors release H2S or affect its synthesis. As a result, they have progressed through the development process into widespread clinical use and become increasingly important. The present study draws a detailed discussion on the types of H2S donors and inhibitors and their role in cancer research. We believe that this state-of-the-art review will empower the synthesis of H2S -based chemopreventive drugs and promote the need for further in-depth exploration of the associations between H2S and cancer treatments in clinical settings.

H2S donors
H2S inhibitors
Hydrogen sulfide
National Natural Science Foundation of China

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Conflict of interest
All the authors declare no conflicts of interest.
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Gene & Protein in Disease, Electronic ISSN: 2811-003X Print ISSN: TBA, Published by AccScience Publishing