AccScience Publishing / GPD / Volume 1 / Issue 2 / DOI: 10.36922/gpd.v1i2.118

Recent insights into USP7: Construct, pathophysiology, and inhibitors

Yuanming He1 Yueya Zhong1 Yiqian Wang2 Xinliang Mao1*
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1 Guangzhou and Guangdong Key Laboratory of Protein Modification and Degradation, School of Basic Medical Sciences and State Key Laboratory of Respiratory Diseases, Guangzhou Medical University, Panyu District, Guangzhou, 511436, China
2 School of Biological Sciences, Guangzhou Medical University, Panyu District, Guangzhou, 511436, China
Submitted: 30 May 2022 | Accepted: 18 July 2022 | Published: 15 August 2022
© 2022 by the Authors. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( )

The ubiquitin-proteasome pathway (UPP) is essential for proteostasis and cellular homeostasis. Most of the human proteins are degraded through the UPP in which proteins should be tagged with a specific polyubiquitin chain in a sequential cascade of E1 ubiquitin (Ub)-activating enzymes, namely, E2 Ub-conjugating enzymes and E3 Ub ligases. Meanwhile, the ubiquitination process can be reversed by deubiquitinating enzymes (DUBs), which protect the target proteins from ubiquitination, and so far, around 100 DUBs have been reported to present in human cells. Ubiquitin-specific protease 7 (USP7) is a member of the DUBs family, which has been reported to play crucial role in the development of human tumors and diseases; however, the molecular mechanisms of disease and malignant tumor progression mediated by USP7 has not been fully elucidated. In addition, the therapeutic potential of USP7 in cancer treatment remains to be further explored. Therefore, this review begins with a review of the structure and function of USP7, and then focuses on the development of USP7 inhibitors and their potential applications in various human diseases.

Ubiquitin-proteasome pathway
Deubiquitinating enzymes
Ubiquitin specific protease 7
Molecule inhibitors
Guangzhou Medical University Discipline Construction Funds (Basic Medicine)

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Conflict of interest
The authors declare that they have no competing interests.
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Gene & Protein in Disease, Electronic ISSN: 2811-003X Published by AccScience Publishing