Ebola outbreak in the Democratic Republic of the Congo: Lessons from Kasai (2025) and emerging challenges from the Bundibugyo resurgence
On December 1, 2025, the Democratic Republic of the Congo declared the end of its 16th Ebola virus disease outbreak in Kasai Province after 42 days without new cases. The outbreak involved 64 cases (53 confirmed, 11 probable) and 45 deaths. Response measures included enhanced surveillance, rapid isolation, ring vaccination with Ebola Zaire Vaccine, Live (ERVEBO), and strengthened infection prevention and control. More than 44,000 individuals were vaccinated, while monoclonal antibody therapies and early referral contributed to reduced mortality. This commentary synthesizes epidemiological, immunological, and operational lessons from the Kasai outbreak, emphasizing surveillance, vaccination strategies, and community engagement for future preparedness. Recent developments highlight the evolving threat of Ebola, with the ongoing 17th outbreak caused by the Bundibugyo virus in the Democratic Republic of the Congo. As of July 2026, over 1,560 cases and more than 506 deaths have been reported, with cross-border transmission and no licensed vaccines, underscoring the need for strengthened regional response strategies.
- World Health Organization. Democratic Republic of the Congo declares Ebola virus disease outbreak in Kasai Province. World Health Organization,. Updated September 04, 2025. Accessed June 14, 2026. https://www.afro.who.int/ countries/democratic-republic-of-congo/news/democratic-republic-congo-declares-ebola-virus-disease-outbreak-kasai-province
- World Health Organization. Ebola virus disease - Democratic Republic of the Congo. Updated May 14, 2026. Accessed June 14, 2026. https://www.who.int/emergencies/ emergency-events/item/2025-DON589
- AfricaCDC. Ebola Outbreak in the DRC Declared Over. AfricaCDC. Updated December 2, 2025. Accessed June 14, 2026. https://africacdc.org/news-item/ebola-outbreak-in-the-drc-declared-over/
- Choudhary D, Srinivas MN, Narayana Murthy BS, Ahmad Naik P. A review of the effect of environmental factors on COVID-19 disease. Innov Emerg Technol. 2025;12:2530005. doi: 10.1142/S2737599425300053
- Mwamba DK, Angendu KB, Diouf W, et al. Seven Strategies Implemented in Response to the 16th Ebola Virus Disease Outbreak in the Democratic Republic of Congo: Lessons Learned over a Three-Month Period. Viruses. 2025;18(1):28. doi: 10.3390/v18010028
- UNICEF DRC. Government declares end to Ebola outbreak in DR Congo. Updated December 1, 2025. Accessed June 14, 2026. https://www.unicef.org/drcongo/en/press-releases/ government-declares-end-ebola-outbreak-dr-congo
- Food & Drug Administration. First FDA‑approved vaccine for prevention of Ebola (ERVEBO). Updated December 19, 2019. Accessed June 10, 2026. https://www.fda.gov/ media/133757/download
- Kikwango EM, Akilimali PZ, Tran NT. Impact of most promising Ebola therapies on survival: a secondary analysis during the tenth outbreak in the Democratic Republic of Congo. Virol J. 2025;22(1):144. doi: 10.1186/s12985-025-02766-y
- Dyer O. Two Ebola treatments halve deaths in trial in DRC outbreak. BMJ. 2019;366. doi: 10.1136/bmj.l5140
- Prasad AN, Woolsey C, Borisevich V, et al. Remdesivir, mAb114, REGN-EB3, and ZMapp partially rescue nonhuman primates infected with a low passage Kikwit variant of Ebola virus. Nat Commun. 2025;16(1):3824. doi: 10.1038/s41467-025-59168-5
- Hartley C, Bavinger JC, Kuthyar S, Shantha JG, Yeh S. Pathogenesis of uveitis in Ebola virus disease survivors: evolving understanding from outbreaks to animal models. Microorganisms. 2020;8(4):594. doi: 10.3390/microorganisms8040594
- Lee H-N, Xu B, Lewkowicz AP, et al. Ebola virus-induced eye sequelae: a murine model for evaluating glycoprotein-targeting therapeutics. EBioMedicine. 2024;104:105170. doi: 10.1016/j.ebiom.2024.105170
- CDC. History of Ebola Outbreaks. Accessed June 14, 2026. https://www.cdc.gov/ebola/outbreaks/index.html
- Biek R, Walsh PD, Leroy EM, Real LA. Recent common ancestry of Ebola Zaire virus found in a bat reservoir. PLoS Pathog. 2006;2(10):e90. doi: 10.1371/journal.ppat.0020090.
- Pigott DM, Golding N, Mylne A, et al. Mapping the zoonotic niche of Ebola virus disease in Africa. eLife. 2014;3:e04395. doi: 10.7554/eLife.04395.
- World Health Organization. North Kivu/Ituri, Democratic Republic of the Congo, August 2018 - June 2020. Accessed June 14, 2026. https://www.who.int/emergencies/situations/ Ebola-2019-drc-#:~:text=Latest%20numbers%20as%20 of%203%20July%202020&text=Total%20of%203481%20 cases%20(3323,people%20died%20and%201162%20 survived.
- Ngongo N, Belizaire MR, Mercy K, et al. WHO and Africa CDC declare the 2026 Ebola disease outbreak a public health emergency. Lancet. 2026;407(10547):2497-2498. doi: 10.1016/s0140-6736(26)01101-3
- World Health Organization. Alert and response - Daily epidemiological update on acute public health events. Updated July 4, 2026. Accessed July 6, 2026. https://www. who.int/emergencies/alert-and-response