Microwork, a form of digital labor mediated through platforms, is marked by precarious conditions such as low pay, long hours, and a lack of social protection. Although research has highlighted its psychosocial risks, little is known about its psychosomatic consequences. This study examines the relationships between work–family conflict, perceived stress, job satisfaction, and musculoskeletal symptoms among 358 Brazilian microworkers. Participants (mean age = 28.15 years, standard deviation = 6.54; 60% women) completed validated measures of work–family conflict, stress, job satisfaction, and musculoskeletal complaints through an online survey conducted in mid-2025. Descriptive statistics revealed long working hours, low income, and high prevalence of musculoskeletal symptoms, especially in the neck, shoulders, back, and wrists/hands. Psychometric analyses confirmed adequate reliability and factorial validity of the instruments. Group comparisons showed that women, married participants, and those with children experienced higher levels of conflict, stress, and symptoms, along with lower job satisfaction. Structural equation modeling supported the hypothesized psychosomatic pathway: Work–family conflict was positively associated with stress, which in turn predicted musculoskeletal complaints, while job satisfaction partially mediated these associations. Overall, the findings demonstrate that psychosocial risks in microwork are embodied in somatic symptoms, disproportionately affecting women and individuals with family responsibilities. By situating microwork within a psychosomatic framework, this study highlights the urgent need for interventions that integrate psychosocial risk management and health protection strategies for digital platform workers.