AccScience Publishing / JCBP / Online First / DOI: 10.36922/jcbp.5084
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ORIGINAL RESEARCH ARTICLE

Association of high-density lipoprotein-related inflammatory markers with suicidal ideation: Data from the NHANES 2015 – 2023 survey

Zhonghua Sun1 ,  Sen Chen1 ,  Yameng Xu2 ,  Chen Qu1*
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1 Department of Geriatrics, The Second Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
2 Department of Epidemiology, School of Public Health of Nanjing Medical University, Nanjing, Jiangsu, China
JCBP, 5084 https://doi.org/10.36922/jcbp.5084
Submitted: 8 October 2024 | Revised: 20 October 2024 | Accepted: 13 November 2024 | Published: 17 December 2024
© 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Suicidal ideation (SI) is a strong predictor of suicide risk. High-density lipoprotein (HDL)-related inflammatory indicators, which combine HDL cholesterol (HDL-C) with other inflammation-related markers, provide a comprehensive assessment of the body’s inflammatory, immune, and metabolic states. However, limited research has examined the association between HDL-related inflammatory indicators and SI. This study analyzed data from 14,554 participants, including 588 individuals with SI, using information from the 2015 – 2023 National Health and Nutrition Examination Survey. SI was evaluated using the ninth item of the Patient Health Questionnaire-9. A weighted approach was applied to logistic regression, restricted cubic spline, and subgroup analyses to explore the relationship between six HDL-related inflammatory indicators and SI. In addition, weighted quantile sum regression was employed to account for the interactions among inflammatory markers and their influence on the outcomes. Among the various single-marker models, only high-sensitivity C-reactive protein/HDL-C (CHR) consistently demonstrated a significant linear association with SI. In Model 3 of the logistic regression analysis, the odds ratio with a 95% confidence interval was 1.11 (1.02, 1.21). Mixture analyses further identified CHR as the primary factor contributing to the increased prevalence of SI. This study provides the first epidemiological evidence linking multiple novel inflammatory markers to SI, identifying CHR as the most critical factor. Further prospective studies are needed to confirm this causal relationship.

Graphical abstract
Keywords
Suicidal ideation
Patient Health Questionnaire-9
High-density lipoprotein-related inflammatory indicators
National Health and Nutrition Examination Survey
Funding
This study was supported by the Natural Science Foundation of Jiangsu Province (Grant No. BK20242002).
Conflict of interest
Chen Qu is an Editorial Board Member of this journal but was not in any way involved in the editorial and peer-review process conducted for this paper, directly or indirectly. Separately, other authors declared that they have no known competing financial interests or personal relationships that could have influenced the work reported in this paper.
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Journal of Clinical and Basic Psychosomatics, Electronic ISSN: 2972-4414 Print ISSN: 3060-8562, Published by AccScience Publishing
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