AccScience Publishing / JCBP / Online First / DOI: 10.36922/jcbp.3890
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ORIGINAL RESEARCH ARTICLE

Exploring the role of genetic factors in personality disorders among women with heroin dependence

Kadir Uludag1* ,  Hang Su1 ,  Haifeng Jiang1 ,  Na Zhong1 ,  Jiang Du1 ,  Min Zhao1
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1 Shanghai Mental Health Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, China
JCBP 2024, 2(4), 3890 https://doi.org/10.36922/jcbp.3890
Submitted: 7 June 2024 | Accepted: 22 July 2024 | Published: 4 October 2024
© 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Heroin dependence is a severe psychiatric issue that often coexists with mood disorders and personality disorders, which further compound the complexity and severity of the dependence. The utilization of genetic factors in predicting psychiatric disorders has made notable advancements. We enrolled female patients diagnosed with heroin dependence (n = 263) and assessed individuals with paranoid personality disorder, depressive personality disorder, antisocial personality disorder, and schizoid personality disorder based on the DSM-IV criteria. Our objective was to examine the single nucleotide polymorphisms (SNPs; rs174696, rs174699, rs4680, rs4818, rs737866, rs933271, rs12953076b, and rs44458044b) and their association with personality. We discovered a significant association of antisocial personality disorder with rs1544325, rs4680, and rs4818 (P < 0.05). Additionally, hallucinogen use was associated with rs3792738 (P < 0.05), rs10062367 (P < 0.05), and rs1875999 (P < 0.01). However, we did not observe a relationship between the SNPs and schizoid personality disorder, paranoid personality disorder, or depressive personality disorder. Heroin dependence is linked to specific personality disorders, particularly antisocial personality disorder. The influence of genetic factors could have a significant impact on the emergence of personality alterations linked to the consumption of heroin.

Keywords
Heroin dependence
Heroin dependence treatment
Drug addiction
Psychotic disorder
Personality disorder
Hallucinogen use
Antisocial personality disorder
Funding
None.
Conflict of interest
The authors declare that they have no competing interests.
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