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ORIGINAL RESEARCH ARTICLE

Exploring the role of genetic factors in personality disorders among women with heroin dependence

Kadir Uludag1* ,  Hang Su1 ,  Haifeng Jiang1 ,  Na Zhong1 ,  Jiang Du1 ,  Min Zhao1
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1 Shanghai Mental Health Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, China
JCBP, 3890 https://doi.org/10.36922/jcbp.3890
Submitted: 7 June 2024 | Accepted: 22 July 2024 | Published: 4 October 2024
© 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Heroin dependence is a severe psychiatric issue that often coexists with mood disorders and personality disorders, which further compound the complexity and severity of the dependence. The utilization of genetic factors in predicting psychiatric disorders has made notable advancements. We enrolled female patients diagnosed with heroin dependence (n = 263) and assessed individuals with paranoid personality disorder, depressive personality disorder, antisocial personality disorder, and schizoid personality disorder based on the DSM-IV criteria. Our objective was to examine the single nucleotide polymorphisms (SNPs; rs174696, rs174699, rs4680, rs4818, rs737866, rs933271, rs12953076b, and rs44458044b) and their association with personality. We discovered a significant association of antisocial personality disorder with rs1544325, rs4680, and rs4818 (P < 0.05). Additionally, hallucinogen use was associated with rs3792738 (P < 0.05), rs10062367 (P < 0.05), and rs1875999 (P < 0.01). However, we did not observe a relationship between the SNPs and schizoid personality disorder, paranoid personality disorder, or depressive personality disorder. Heroin dependence is linked to specific personality disorders, particularly antisocial personality disorder. The influence of genetic factors could have a significant impact on the emergence of personality alterations linked to the consumption of heroin.

Keywords
Heroin dependence
Heroin dependence treatment
Drug addiction
Psychotic disorder
Personality disorder
Hallucinogen use
Antisocial personality disorder
Funding
None.
Conflict of interest
The authors declare that they have no competing interests.
References
  1. Fassino S, Abbate Daga G, Delsedime N, Rogna L, Boggio S. Quality of life and personality disorders in heroin abusers. Drug Alcohol Depend. 2004;76(1):73-80. doi: 10.1016/j.drugalcdep.2004.04.005

 

  1. Moustafa AA, Tindle R, Cashel S, Parkes D, Mohamed E, Abo Hamza E. Bidirectional relationship between heroin addiction and depression: Behavioural and neural studies. Curr Psychol. 2022;41:5195-5211. doi: 10.1007/s12144-020-01032-4

 

  1. Dettmeyer R, Friedrich K, Schmidt P, Madea B. Heroin-associated myocardial damages-conventional and immunohistochemical investigations. Forensic Sci Int. 2009;187(1):42-46. doi: 10.1016/j.forsciint.2009.02.014

 

  1. Abed H, Hassona Y. Oral healthcare management in heroin and methadone users. Br Dent J. 2019;226(8):563-567. doi: 10.1038/s41415-019-0206-x

 

  1. Tolomeo S, Steele JD, Ekhtiari H, Baldacchino A. Chronic heroin use disorder and the brain: Current evidence and future implications. Prog Neuropsychopharmacol Biol Psychiatry. 2020;111:110148. doi: 10.1016/j.pnpbp.2020.110148

 

  1. Cheng GL, Zeng H, Leung MK, et al. Heroin abuse accelerates biological aging: A novel insight from telomerase and brain imaging interaction. Transl Psychiatry. 2013;3(5):e260. doi: 10.1038/tp.2013.36

 

  1. Cai HB, Miao X, Lin Z, et al. Structural and functional characteristics of impulsive-related brain regions in heroin addicts with long-term withdrawal. Acta Psychol Sin. 2021;53:861-874. doi: 10.3724/SP.J.1041.2021.00861

 

  1. Gerra G, Zaimovic A, Moi G, et al. Aggressive responding in abstinent heroin addicts: Neuroendocrine and personality correlates. Prog Neuropsychopharmacol Biol Psychiatry. 2004;28(1):129-139. doi: 10.1016/j.pnpbp.2003.09.029

 

  1. Ceceli AO, King SG, McClain N, Alia-Klein N, Goldstein RZ. The neural signature of impaired inhibitory control in individuals with heroin use disorder. J Neurosci. 2023;43(1):173-182. doi: 10.1523/JNEUROSCI.1237-22.2022

 

  1. Chen YZ, Huang WL, Shan JC, Lin YH, Chang HC, Chang LR. Self-reported psychopathology and health-related quality of life in heroin users treated with methadone. Neuropsychiatr Dis Treat. 2012;9:41-48. doi: 10.2147/NDT.S37284

 

  1. Zapolski TC, Cyders MA, Smith GT. Positive urgency predicts illegal drug use and risky sexual behavior. Psychol Addict Behav. 2009;23(2):348-354. doi: 10.1037/a0014684

 

  1. Maremmani I, Pani PP, Pacini M, et al. Subtyping patients with heroin addiction at treatment entry: Factor derived from the Self-Report Symptom Inventory (SCL-90). Ann Gen Psychiatry. 2010;9(1):15. doi: 10.1186/1744-859X-9-15

 

  1. Pau CW, Lee TM, Chan SF. The impact of heroin on frontal executive functions. Arch Clin Neuropsychol. 2002;17(7):663-670. doi: 10.1093/arclin/17.7.663

 

  1. Darke S, Williamson A, Ross J, Teesson M, Lynskey M. Borderline personality disorder, antisocial personality disorder and risk-taking among heroin users: Findings from the Australian Treatment Outcome Study (ATOS). Drug Alcohol Depend. 2004;74(1):77-83. doi: 10.1016/j.drugalcdep.2003.12.002

 

  1. Yang M, Mamy J, Zhou L, et al. Gender differences in prevalence and correlates of antisocial personality disorder among heroin dependent users in compulsory isolation treatment in China. Addict Behav. 2014;39(3):573-579. doi: 10.1016/j.addbeh.2013.11.003

 

  1. Walter M, Degen B, Treugut C, et al. Affective reactivity in heroin-dependent patients with antisocial personality disorder. Psychiatr Res. 2011;187(1):210-213. doi: 10.1016/j.psychres.2010.10.017

 

  1. Hopwood CJ, Baker KL, Morey LC. Personality and drugs of choice. Pers Individ Dif. 2008;44(6):1413-1421. doi: 10.1016/j.paid.2007.12.009

 

  1. Fehrman E, Egan V, Gorban AN, et al. Drug use and personality profiles. In: Personality Traits and Drug Consumption: A Story Told by Data. Cham: Springer; 2019. p. 5-33. doi: 10.1007/978-3-030-10442-9

 

  1. Penke L, Denissen JJA, Miller GF. The evolutionary genetics of personality. Eur J Pers. 2007;21(5):549-587. doi: 10.1002/per.629

 

  1. Silverman S. Identification of Shared Gene/Drug and Gene/Disease Genetic Associations in a Mental Health/ Substance Use Disorder Patient Population Across an Addiction Treatment Network Using Pharmacogenomic Testing. Research Square [Preprint]; 2023.

 

  1. Teh LK, Izuddin AF, Fazleen HM, Zakaria ZA, Salleh MZ. Tridimensional personalities and polymorphism of dopamine D2 receptor among heroin addicts. Biol Res Nurs. 2012;14(2):188-196. doi: 10.1177/1099800411405030

 

  1. Akil M, Kolachana BS, Rothmond DA, Hyde TM, Weinberger DR, Kleinman JE. Catechol-O-methyltransferase genotype and dopamine regulation in the human brain. J Neurosci. 2003;23(6):2008-2013. doi: 10.1523/JNEUROSCI.23-06-02008.2003

 

  1. Montag C, Jurkiewicz M, Reuter M. The role of the catechol- O-methyltransferase (COMT) gene in personality and related psychopathological disorders. CNS Neurol Disord Drug Targets. 2012;11(3):236-250. doi: 10.2174/187152712800672382

 

  1. Scheggia D, Sannino S, Luisa Scattoni M, Papaleo F. COMT as a drug target for cognitive functions and dysfunctions. CNS Neurol Disord Drug Targets. 2012;11(3):209-221. doi: 10.2174/187152712800672481

 

  1. Opmeer EM, Kortekaas R, van Tol MJ, et al. Influence of COMT val158met genotype on the depressed brain during emotional processing and working memory. PLoS One. 2013;8(9):e73290. doi: 10.1371/journal.pone.0073290

 

  1. Martens WH. Schizoid personality disorder linked to unbearable and inescapable loneliness. Eur J Psychiatry. 2010;24(1):38-45. doi: 10.4321/S0213-61632010000100005

 

  1. Dissabandara LO, Loxton NJ, Dias SR, Dodd PR, Daglish M, Stadlin A. Dependent heroin use and associated risky behaviour: The role of rash impulsiveness and reward sensitivity. Addict Behav. 2014;39(1):71-76. doi: 10.1016/j.addbeh.2013.06.009

 

  1. Holzer KJ, Vaughn MG, Fearn NE, Loux TM, Mancini MA. Age bias in the criteria for antisocial personality disorder. J Psychiatr Res. 2021;137:444-451. doi: 10.1016/j.jpsychires.2021.03.025

 

  1. Milivojevic D, Milovanovic SD, Jovanovic M, et al. Temperament and character modify risk of drug addiction and ınfluence choice of drugs. Am J Addict. 2012;21(5):462-467. doi: 10.1111/j.1521-0391.2012.00251.x

 

  1. Wingo T, Nesil T, Choi JS, Li MD. Novelty seeking and drug addiction in humans and animals: From behavior to molecules. J Neuroimmune Pharmacol. 2016;11(3):456-470. doi: 10.1007/s11481-015-9636-7

 

  1. Gocłowska MA, Ritter SM, Elliot AJ, Baas M. Novelty seeking is linked to openness and extraversion, and can lead to greater creative performance. J Pers. 2019;87(2):252-266. doi: 10.1111/jopy.12387

 

  1. Schindler A, Thomasius R, Petersen K, Sack PM. Heroin as an attachment substitute? Differences in attachment representations between opioid, ecstasy and cannabis abusers. Attach Hum Dev. 2009;11(3):307-330. doi: 10.1080/14616730902815009

 

  1. Liao Y, Tang J, Liu T, Chen X, Luo T, Hao W. Sleeping problems among Chinese heroin-dependent individuals. Am J Drug Alcohol Abuse. 2011;37(3):179-183. doi: 10.3109/00952990.2010.535580

 

  1. Mastin DF, Peszka J, Poling T, Phillips R, Duke J. Personality as a predictor of the objective and subjective impact of sleep deprivation. Pers Individ Dif. 2005;39(8):1471-1482. doi: 10.1016/j.paid.2005.08.007

 

  1. Farrell M, Boys A, Bebbington P, et al. Psychosis and drug dependence: Results from a national survey of prisoners. Br J Psychiatr. 2018;181(5):393-398. doi: 10.1192/bjp.181.5.393

 

  1. Parnes JE, Kentopp SD, Conner BT, Rebecca RA. Who takes the trip? Personality and hallucinogen use among college students and adolescents. Drug Alcohol Depend. 2020;217:108263. doi: 10.1016/j.drugalcdep.2020.108263

 

  1. Pedersen K, Waal H, Kringlen E. Patients with nonaffective psychosis are at increased risk for heroin use disorders. Eur Addict Res. 2012;18(3):124-129. doi: 10.1159/000334613

 

  1. Rognli EB, Berge J, Håkansson A, Bramness JG. Long-term risk factors for substance-induced and primary psychosis after release from prison. A longitudinal study of substance users. Schizophr Res. 2015;168(1):185-190. doi: 10.1016/j.schres.2015.08.032

 

  1. Mills KL, Teesson M, Darke S, Ross J, Lynskey M. Young people with heroin dependence: Findings from the Australian Treatment Outcome Study (ATOS). J Substance Abuse Treat. 2004;27(1):67-73. doi: 10.1016/j.jsat.2004.05.001

 

  1. Frankel PS, Cunningham KA. The hallucinogen d-lysergic acid diethylamide (d-LSD) induces the immediate-early gene c-Fos in rat forebrain. Brain Res. 2002;958(2):251-260. doi: 10.1016/S0006-8993(02)03548-5

 

  1. Reichborn-Kjennerud T. The genetic epidemiology of personality disorders. Dialogues Clin Neurosci. 2022; 12(1):103-114.

 

  1. Goldman D, Oroszi G, Ducci F. The genetics of addictions: Uncovering the genes. Focus. 2006;4(3):401-415. doi: 10.1176/foc.4.3.401

 

  1. Gerra G, Garofano L, Santoro G, et al. Association between low-activity serotonin transporter genotype and heroin dependence: Behavioral and personality correlates. Am J Med Genet Part B Neuropsychiatr Genet. 2004;126B(1):37-42. doi: 10.1002/ajmg.b.20111

 

  1. Ducci F, Goldman D. The genetic basis of addictive disorders. Psychiatr Clin. 2012;35(2):495-519. doi: 10.1016/j.psc.2012.03.010

 

  1. Grant JE, Lust K, Chamberlain SR. Hallucinogen use is associated with mental health and addictive problems and impulsivity in university students. Addict Behav Reports. 2019;10:100228. doi: 10.1016/j.abrep.2019.100228

 

  1. Martin DA, Nichols CD. The effects of hallucinogens on gene expression. In: Behavioral Neurobiology of Psychedelic Drugs. Berlin: Springer; 2018. p. 137-158.

 

  1. Chaudhary A, Kumar P, Rai V. Catechol-O-methyltransferase (COMT) Val158Met polymorphism and susceptibility to alcohol dependence. Indian J Clin Biochem. 2021;36(3):257-265. doi: 10.1007/s12291-020-00933-2

 

  1. Martínez-Magaña JJ, Genis-Mendoza AD, González- Covarrubias V, et al. Association of FAAH p.Pro129Thr and COMT p.Ala72Ser with schizophrenia and comorbid substance use through next-generation sequencing: An exploratory analysis. Braz J Psychiatry. 2022;44:164-170. doi: 10.1590/1516-4446-2020-1546

 

  1. Tommasi M, Sergi MR, Konstantinidou F, et al. Association of COMT, BDNF and 5-HTT functional polymorphisms with personality characteristics. Front Biosci. 2021;26(11):1064-1074. doi: 10.52586/5009

 

  1. Da Costa Azevedo JN, Carvalho C, Serrão MP, Coelho R, Figueiredo-Braga M, Vieira-Coelho MA. Catechol-O-methyltransferase activity in individuals with substance use disorders: A case control study. BMC Psychiatry. 2022;22(1):412. doi: 10.1186/s12888-022-04068-x

 

  1. Triebwasser J, Chemerinski E, Roussos P, Siever LJ. Schizoid personality disorder. J Pers Disord. 2012;26(6):919-926. doi: 10.1521/pedi.2012.26.6.919

 

  1. Kalayasiri R, Kranzler HR, Weiss R, et al. Risk factors for cocaine-induced paranoia in cocaine-dependent sibling pairs. Drug Alcohol Depend. 2006;84(1):77-84. doi: 10.1016/j.drugalcdep.2005.12.002

 

  1. Leamon MH, Flower K, Salo RE, Nordahl TE, Kranzler HR, Galloway GP. Methamphetamine and paranoia: The methamphetamine experience questionnaire. Am J Addict. 2010;19(2):155-168. doi: 10.1111/j.1521-0391.2009.00014.x

 

  1. Becir K. P-09-Psychiatric comorbidity of heroin dependence and personality disorders and treatment within work-occupational therapy. Eur Psychiatry. 2012;27(S1):1. doi: 10.1016/S0924-9338(12)74176-7

 

  1. Black DW, Gunter T, Loveless P, Allen J, Sieleni B. Antisocial personality disorder in incarcerated offenders: Psychiatric comorbidity and quality of life. Ann Clin Psychiatry. 2010;22(2):113-120.

 

  1. Vassileva J, Petkova P, Georgiev S, et al. Impaired decision-making in psychopathic heroin addicts. Drug Alcohol Depend. 2007;86(2):287-289. doi: 10.1016/j.drugalcdep.2006.06.015

 

  1. Yang M, Kavi V, Wang W, Wu Z, Hao W. The association of 5-HTR2A-1438A/G, COMTVal158Met, MAOA-LPR, DATVNTR and 5-HTTVNTR gene polymorphisms and antisocial personality disorder in male heroin-dependent Chinese subjects. Prog Neuropsychopharmacol Biol Psychiatry. 2012;36(2):282-289. doi: 10.1016/j.pnpbp.2011.11.009

 

  1. Pietrzak RH, Petry NM. Antisocial personality disorder is associated with increased severity of gambling, medical, drug and psychiatric problems among treatment‐seeking pathological gamblers. Addiction. 2005;100(8):1183-1193. doi: 10.1111/j.1360-0443.2005.01151.x

 

  1. Shepherd SM, Campbell RE, Ogloff JR. Psychopathy, antisocial personality disorder, and reconviction in an Australian sample of forensic patients. Int J Offender Ther Comp Criminol. 2018;62(3):609-628. doi: 10.1177/0306624X16653193

 

  1. Sukhareva EV. The role of the corticotropin-releasing hormone and its receptors in the regulation of stress response. Vavilov J Genet Breed. 2021;25(2):216-223. doi: 10.18699/VJ21.025

 

  1. Vevera J, Stopkova R, Bes M, et al. COMT polymorphisms in impulsively violent offenders with antisocial personality disorder. Neuro Endocrinol Lett. 2009;30(6):753-756.

 

  1. Qayyum A, Zai C, Hirata Y, et al. The role of the catechol-o-methyltransferase (COMT) GeneVal158Met in aggressive behavior, a review of genetic studies. Curr Neuropharmacol. 2015;13(6):802-814. doi: 10.2174/1570159X13666150612225836

 

  1. Wise RA, Robble MA. Dopamine and Addiction. Ann Rev Psychol. 2020;71(1):79-106. doi: 10.1146/annurev-psych-010418-103337

 

  1. Buckholtz JW, Treadway MT, Cowan RL, et al. Mesolimbic dopamine reward system hypersensitivity in individuals with psychopathic traits. Nat Neurosci. 2010;13(4):419-421. doi: 10.1038/nn.2510

 

  1. Shea MT, Glass DR, Pilkonis PA, Watkins J, Docherty JP. Frequency and implications of personality disorders in a sample of depressed outpatients. J Pers Disord. 1987;1(1):27-42. doi: 10.1521/pedi.1987.1.1.27

 

  1. Groenman AP, Janssen TW, Oosterlaan J. Childhood psychiatric disorders as risk factor for subsequent substance abuse: A meta-analysis. J Am Acad Child Adolesc Psychiatr. 2017;56(7):556-569. doi: 10.1016/j.jaac.2017.05.004

 

  1. Sanja TV, Elizabeta DH, Klementina R. The relationship between personality traits and anxiety/depression levels in different drug abusers’ groups. Ann Ist Super Sanita. 2013;49:365-369. doi: 10.4415/ANN_13_04_08

 

  1. Potik D. Kleinian conceptualization of heroin addiction, part 1: The Paranoid-Schizoid position. Clin Soc Work J. 2018;46(1):34-41. doi: 10.1007/s10615-016-0609-y

 

  1. Craig RJ. Personality characteristics of heroin addicts: A review of the empirical literature with Critique-part II. Int J Addict. 1979;14(5):607-626. doi: 10.3109/10826087909041894
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