AccScience Publishing / JCBP / Volume 0 / Issue 0 / DOI: 10.36922/jcbp.4864
CASE REPORT

Psychogenic fever and palpitations in a patient with autonomic nervous system dysfunction: A case report

Rong Chen1,2 Rongjing Ding1*
Show Less
1 Department of Rehabilitation, Peking Union Medical College Hospital, Beijing, China
2 Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Submitted: 16 September 2024 | Revised: 5 January 2025 | Accepted: 10 January 2025 | Published: 14 February 2025
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

Mental health disorders are prevalent in cardiovascular disease patients, yet often remain under-recognized. Psychogenic fever (PF), a psychosomatic condition triggered by stress, may present as a fever of unknown origin, complicating the diagnostic process. This case report describes a 58-year-old male diagnosed with PF, a stress-induced psychosomatic disorder associated with autonomic nervous system (ANS) dysfunction. The patient presented with a 1-year history of recurrent low-grade fever and palpitations, which remained unexplained despite comprehensive laboratory and imaging evaluations. Psychometric assessments revealed chronic stress, mild depression, and moderate anxiety, suggesting psychological stress as the potential cause of PF. ANS evaluation indicated mild impairment in heart rate variability. The patient’s significant improvement with anti-anxiety and antidepressant treatment confirmed the diagnosis of ANS dysfunction and PF. This case highlights the importance of incorporating psychometric and physio-psychological assessments into the diagnostic workup for unexplained fever, advocating for the consideration of mental health disorders after ruling out organic causes.

Keywords
Psychogenic fever
Autonomic nervous system dysfunction
Cardiology
Psychosomatic disorder
Anxiety
Palpitations
Funding
None.
Conflict of interest
The authors declare that they have no competing interests.
References
  1. Grace SL, Abbey SE, Irvine J, Shnek ZM, Stewart DE. Prospective examination of anxiety persistence and its relationship to cardiac symptoms and recurrent cardiac events. Psychother Psychosom. 2004;73(6):344-352. doi: 10.1159/000080387

 

  1. Krittanawong C, Maitra NS, Qadeer YK, et al. Association of depression and cardiovascular disease. Am J Med. 2023;136(9):881-895. doi: 10.1016/j.amjmed.2023.04.036

 

  1. Emdin CA, Odutayo A, Wong CX, Tran J, Hsiao AJ, Hunn BH. Meta-analysis of anxiety as a risk factor for cardiovascular disease. Am J Cardiol. 2016;118(4):511-519. doi: 10.1016/j.amjcard.2016.05.041

 

  1. Song WX, Tan L, Li HL, Huang GP, He Q, An S. A survey of the prevalence of depression and anxiety disorders among patient attendees with cardiovascular disease in primary hospitals. J Chongqing Med Univ. 2012;37(10):911-913. doi: 10.3969/j.issn.0253-3626.2012.10.018

 

  1. Benjenk I, Chen J. Effective mental health interventions to reduce hospital readmission rates: A systematic review. J Hosp Manag Health Policy. 2018;2:45. doi: 10.21037/jhmhp.2018.08.05.

 

  1. Meuret AE, Tunnell N, Roque A. Anxiety disorders and medical comorbidity: Treatment implications. Adv Exp Med Biol. 2020;1191:237-261. doi: 10.1007/978-981-32-9705-0_15

 

  1. PSYCHOGENIC fever. Br Med J. 1959;1(5136):1517-1518.

 

  1. Moltz H. Fever: Causes and consequences. Neurosci Biobehav Rev. 1993;17(3):237-269. doi: 10.1016/s0149-7634(05)80009-0

 

  1. Olivier B. Psychogenic fever, functional fever, or psychogenic hyperthermia? Temperature (Austin). 2015;2(3):324-325. doi: 10.1080/23328940.2015.1071701

 

  1. Ishizaki Y, Yanagimoto Y, Fujii Y, Yamamoto M, Kaneko K. Psychogenic fever and postural tachycardia syndrome among school-aged children and adolescents with fever of unknown origin. Biopsychosoc Med. 2022;16(1):9. doi: 10.1186/s13030-022-00238-1

 

  1. Peltier AC. Autonomic dysfunction from diagnosis to treatment. Prim Care. 2024;51(2):359-373. doi: 10.1016/j.pop.2024.02.006

 

  1. Oka T. Psychogenic fever: How psychological stress affects body temperature in the clinical population. Temperature (Austin). 2015;2(3):368-378. doi: 10.1080/23328940.2015.1056907

 

  1. Costantini L, Pasquarella C, Odone A, et al. Screening for depression in primary care with Patient Health Questionnaire-9 (PHQ-9): A systematic review. J Affect Disord. 2021;279:473-483. doi: 10.1016/j.jad.2020.09.131

 

  1. Stocker R, Tran T, Hammarberg K, Nguyen H, Rowe H, Fisher J. Patient Health Questionnaire 9 (PHQ-9) and General Anxiety Disorder 7 (GAD-7) data contributed by 13,829 respondents to a national survey about COVID-19 restrictions in Australia. Psychiatry Res. 2021;298:113792. doi: 10.1016/j.psychres.2021.113792

 

  1. Liu M, Wang D, Fang J, Chang Y, Hu Y, Huang K. Validation of the generalized anxiety disorder-7 in patients with COPD: A cross-sectional study. BMC Psychiatry. 2023;23(1):593. doi: 10.1186/s12888-023-05072-5

 

  1. Gong Y, Zhou H, Zhang Y, et al. Validation of the 7-item generalized anxiety disorder scale (GAD-7) as a screening tool for anxiety among pregnant Chinese women. J Affect Disord. 2021;282:98-103. doi: 10.1016/j.jad.2020.12.129

 

  1. Shih YC, Chou CC, Lu YJ, Yu HY. Reliability and validity of the traditional Chinese version of the GAD-7 in Taiwanese patients with epilepsy. J Formos Med Assoc. 2022;121(11):2324-2330. doi: 10.1016/j.jfma.2022.04.018

 

  1. Negeri ZF, Levis B, Sun Y, et al. Accuracy of the Patient Health Questionnaire-9 for screening to detect major depression: Updated systematic review and individual participant data meta-analysis. BMJ. 2021;375:n2183. doi: 10.1136/bmj.n2183

 

  1. Wang W, Bian Q, Zhao Y, et al. Reliability and validity of the Chinese version of the Patient Health Questionnaire (PHQ-9) in the general population. Gen Hosp Psychiatry. 2014;36(5):539-544. doi: 10.1016/j.genhosppsych.2014.05.021

 

  1. Zhao Y, Liang Q, Jiang Z, et al. Brain abnormalities in survivors of COVID-19 after 2-year recovery: A functional MRI study. Lancet Reg Health West Pac. 2024;47:101086. doi: 10.1016/j.lanwpc.2024.101086

 

  1. Chalder T, Berelowitz G, Pawlikowska T, et al. Development of a fatigue scale. J Psychosom Res. 1993;37(2):147-153. doi: 10.1016/0022-3999(93)90081-p

 

  1. Wong WS, Fielding R. Construct validity of the Chinese version of the Chalder Fatigue Scale in a Chinese community sample. J Psychosom Res. 2010;68(1):89-93. doi: 10.1016/j.jpsychores.2009.05.008

 

  1. Toussaint A, Kroenke K, Baye F, Lourens S. Comparing the Patient Health Questionnaire - 15 and the somatic symptom scale - 8 as measures of somatic symptom burden. J Psychosom Res. 2017;101:44-50. doi: 10.1016/j.jpsychores.2017.08.002

 

  1. Zhang L, Fritzsche K, Liu Y, et al. Validation of the Chinese version of the PHQ-15 in a tertiary hospital. BMC Psychiatry. 2016;16:89. doi: 10.1186/s12888-016-0798-5

 

  1. Cohen S, Kamarck T, Mermelstein R. A global measure of perceived stress. J Health Soc Behav. 1983;24(4):385-396.

 

  1. Huang F, Wang H, Wang Z, et al. Psychometric properties of the perceived stress scale in a community sample of Chinese. [published correction appears in BMC Psychiatry. 2020;20(1):260. doi: 10.1186/s12888-020-02670-5]. BMC Psychiatry. 2020;20(1):130. doi: 10.1186/s12888-020-02520-4

 

  1. Buysse DJ, Reynolds CF 3rd, Monk TH, Berman SR, Kupfer DJ. The pittsburgh sleep quality index: A new instrument for psychiatric practice and research. Psychiatry Res. 1989;28(2):193-213. doi: 10.1016/0165-1781(89)90047-4

 

  1. Zhang C, Zhang H, Zhao M, et al. Reliability, validity, and factor structure of Pittsburgh sleep quality index in community-based centenarians. Front Psychiatry. 2020;11:573530. doi: 10.3389/fpsyt.2020.573530

 

  1. Yin H, Sui Z, Wang Y, et al. The efficacy and safety of NeuroWell antidepressant dietary supplement, Deanxit, and their combination in the treatment of mild-to-moderate depression: A randomized clinical trial. Genes Dis. 2023;11(6):101171. doi: 10.1016/j.gendis.2023.101171

 

  1. Wang L, Zhong Z, Hu J, et al. Sertraline plus deanxit to treat patients with depression and anxiety in chronic somatic diseases: A randomized controlled trial. BMC Psychiatry. 2015;15:84. doi: 10.1186/s12888-015-0449-2

 

  1. Chen X, Cheng J, Gong J. Deanxit can improve the dizziness, anxiety, and quality of life of patients with chronic subjective dizziness. Am J Transl Res. 2021;13(8):9348-9355.

 

  1. Engel GL. The need for a new medical model: A challenge for biomedicine. Science. 1977;196(4286):129-136. doi: 10.1126/science.847460

 

  1. Cardiovascular Disease Committee of the Chinese Society of Rehabilitation, Cardiovascular Disease Committee of the Chinese Society of Gerontology. Chinese expert consensus on psychological prescription for patients attending cardiovascular departments[J]. Chin J Cardiol. 2014,42(1):6-13. doi: 10.3760/cma.j.issn.0253-3758.2014.01.003

 

  1. Oka T, Oka K. Age and gender differences of psychogenic fever: A review of the Japanese literature. Biopsychosoc Med. 2007;1:11. doi: 10.1186/1751-0759-1-11

 

  1. Miric D, Venet R, Aproh E, Nguyen-Duc H. Psychogenic fever or psychogenic hyperthermia? J Am Geriatr Soc. 1997;45(10):1287-1288. doi: 10.1111/j.1532-5415.1997.tb03796.x

 

  1. Xu M, Zhang X, Xu Z, et al. Psychogenic fever in a patient with small cell lung cancer: A case report. BMC Cancer. 2015;15:445. doi: 10.1186/s12885-015-1462-z

 

  1. Imataki O, Uemura M. Psychogenic fever due to worry about COVID-19: A case report. Clin Case Rep. 2021;9(8):e04560. doi: 10.1002/ccr3.4560

 

  1. Koren SF, Engel LE, Møller MP. Preoperative psychogenic fever: To operate or not to operate. J Surg Case Rep. 2021;2021(3):rjab114. doi: 10.1093/jscr/rjab114

 

  1. Moideen S, Anver PC, Uvais NA, Sreeraj VS, Ul Haq Katshu MZ. Positive naproxen test in psychogenic fever. Prim Care Companion CNS Disord. 2021; 23(3):20l02630. doi: 10.4088/PCC.20l02630

 

  1. McNeil GN, Leighton LH, Elkins AM. Possible psychogenic fever of 103.5 degrees F in a patient with borderline personality disorder. Am J Psychiatry. 1984;141(7):896-897. doi: 10.1176/ajp.141.7.896

 

  1. Wang A, Wang X, Wu P, Huang B. Transient visual impairment in a patient with psychogenic fever: A case report. Am J Emerg Med. 2019;37(8):1601.e1-1601.e2. doi: 10.1016/j.ajem.2019.05.011

 

  1. Hasan MK, White AC. Psychogenic fever: Entity or nonentity? Postgrad Med. 1979;66(2):152-154. doi: 10.1080/00325481.1979.11715228

 

  1. Hiramoto T, Oka T, Yoshihara K, Kubo C. Pyrogenic cytokines did not mediate a stress interview-induced hyperthermic response in a patient with psychogenic fever: A case report. Psychosom Med. 2009;71(9):932-936. doi: 10.1097/PSY.0b013e3181bfb02b

 

  1. O’Toole JK, Dyck G. Report of psychogenic fever in catatonia responding to electroconvulsive therapy. Dis Nerv Syst. 1977;38(10):852-853.

 

  1. White KL, Long WN Jr. The incidence of psychogenic fever in a university hospital. J Chronic Dis. 1958;8(5):567-586. doi: 10.1016/0021-9681(58)90050-x

 

  1. Oka T. Disabling symptoms associated with increased axillary temperature in patients with functional hyperthermia. Biopsychosoc Med. 2024;18(1):9. doi: 10.1186/s13030-024-00306-8

 

  1. Maita H, Kobayashi T, Akimoto T, Osawa H, Kato H. Functional hyperthermia caused by obstructive sleep apnea syndrome: A case report. SAGE Open Med Case Rep. 2022;10:2050313X221123308. doi: 10.1177/2050313X221123308

 

  1. Komamatsu J, Abe M, Miyashita H. Psychogenic fever - the implication of its symptoms: The parent-child relationship in the case of a 10-year-old boy. Kangogaku Zasshi. 1982;46(4):418-423.

 

  1. Shido O. Introduction to the special issue of the journal temperature on Japanese thermal physiology. Temperature (Austin). 2015;2(3):308-309. doi: 10.1080/23328940.2015.1078927

 

  1. Goto F, Morimoto N, Taiji H. Two cases of pediatric psychogenic gait disturbance. Nihon Jibiinkoka Gakkai Kaiho. 2013;116(2):91-96. doi: 10.3950/jibiinkoka.116.91

 

  1. Lkhagvasuren B, Tanaka H, Sudo N, Kubo C, Oka T. Characteristics of the orthostatic cardiovascular response in adolescent patients with psychogenic fever. Psychother Psychosom. 2014;83(5):318-319. doi: 10.1159/000360999

 

  1. Oka T, Oka K, Hori T. Mechanisms and mediators of psychological stress-induced rise in core temperature. Psychosom Med. 2001;63(3):476-486. doi: 10.1097/00006842-200105000-00018

 

  1. Davis JM, Galhn JJ. The neutrophll. In: Oppenheim JJ, Rostenreich DL, Potter M, editors. Cellular Functions in Immunity and Inflammation. Amsterdam: Elsevier; 1981. p. 77-102.

 

  1. Lkhagvasuren B, Nakamura Y, Oka T, Sudo N, Nakamura K. Social defeat stress induces hyperthermia through activation of thermoregulatory sympathetic premotor neurons in the medullary raphe region. Eur J Neurosci. 2011;34:1442-1452. doi: 10.1111/j.1460-9568.2011.07863.x

 

  1. Nakamura K, Morrison SF. Central sympathetic network for thermoregulatory responses to psychological stress. Auton Neurosci. 2022;237:102918. doi: 10.1016/j.autneu.2021.102918

 

  1. Bellinge JW, Tawakol A. Stressing the importance of autonomic nervous system dysfunction. Circ Cardiovasc Imaging. 2024;17(6):e017028. doi: 10.1161/CIRCIMAGING.124.017028

 

  1. Chinese Medical Association, Chinese Society of Psychosomatic Medicine, Chinese Society of Rehabilitation Medicine, Specialized Committee on Cardiovascular Disease Prevention and Rehabilitation, Ding R, et al. Chinese expert consensus on the construction standardization of double heart clinic. Chin Fam Med. 2024;27(3):253-261.

 

Share
Back to top
Journal of Clinical and Basic Psychosomatics, Electronic ISSN: 2972-4414 Print ISSN: 3060-8562, Published by AccScience Publishing