Dear Colleagues:
Additive manufacturing, also known as 3D printing, is driving major innovations in many areas, such as engineering, manufacturing, art, education, and medicine. Recent advances have enabled the 3D bioprinting of biocompatible materials, cells, and supporting components into complex, functional structures, mimicking living tissues. 3D bioprinting has slowly become a cornerstone of modern regenerative medicine, offering a possibility to alleviate the scarcity of transplantable tissues and organs. Undertaking such an ambitious task requires the integration of technologies from the fields of engineering, biomaterial science, cell biology, physics, and medicine. This exciting new technology provides an unparalleled opportunity to design and fabricate tissue constructs, faithfully mimicking the complexity of the native architecture. Current state-of-the-art bioprinters feature a plethora of printheads to choose from, including pneumatic, thermoplastic, temperature-controlled, syringe-pump, electromagnetic droplet depositing, photocuring, and more. This allows for tremendous flexibility in terms of biomaterials and strategies employed to generate desired constructs. 3D bioprinting has already been used for the generation and transplantation of several tissues, including multilayered skin, bone, vascular grafts, tracheal splints, heart tissue, and cartilaginous structures. Other applications include the development of models for research, drug discovery, and toxicology.
Low-temperature deposition 3D printing biotin-doped PLGA/β-TCP scaffold for repair of bone defects in osteonecrosis of femoral head