Stimuli-responsive biomaterials for 3D bioprinting: Bioprinting biomaterials classification (BBC)
Stimuli-responsive biomaterials have progressively developed over the last decade in three-dimensional (3D) bioprinting, enabling dynamic regulation of bioink rheological and processing properties, printing fidelity, and the functional maturation of printed constructs. However, the rapid expansion of responsive materials and bioprinting technologies has led to fragmented and non-standardized definitions of biomaterials and bioinks, resulting in inconsistent classification approaches and complicating the analysis, comparison, and design of emerging systems. This highlights the lack of a unified framework for biomaterial selection for bioprinting. This perspective introduces the bioprinting biomaterials classification (BBC) as a conceptual framework that provides a structured and design-oriented basis for biomaterial selection for bioprinting by linking stimuli-responsive behavior with stage-specific functional requirements across the bioprinting process. The BBC framework classifies biomaterials according to two complementary dimensions: stimulus category (physical, chemical, and biological stimuli) and functional roles across the bioprinting lifecycle (bioink preparation, printing process, post-printing maturation, and in vivo function). This two-level biofunctional classification connects material responsiveness with biofabrication processes and enables a systematic approach to selecting and applying responsive biomaterials based on their stage-specific functional roles. It provides a systematic framework for positioning responsive biomaterials within the biofabrication context and supports a more structured and application-driven approach to biomaterial selection and design in bioprinting systems. By addressing the current lack of structured strategies for biomaterial selection for bioprinting, the BBC framework offers a foundational step toward a more rational and consistent design of responsive biomaterials in advanced biofabrication systems.

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