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Bioprinting in tumor model construction for head and neck squamous cell carcinoma: A review

Yanyan Ding1 ,  Jinwu Chen2 ,  Wenqi Zhong3 ,  Taochen Gu4* ,  Ying Xiao1* ,  Zhenyu Zhao4
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1 Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China
2 Department of Trauma Surgery, CR&WISCO General Hospital, School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, China
3 School of Automation, Northwestern Polytechnical University, Xi’an, Shaanxi, China
4 Department of Electrical and Computer Engineering, Faculty of Engineering, National University of Singapore, Singapore
IJB, 8100 https://doi.org/10.36922/ijb.8100
Submitted: 20 December 2024 | Accepted: 21 January 2025 | Published: 22 January 2025
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Head and neck squamous cell carcinoma (HNSCC) is a malignancy with increasing incidence worldwide, causing a severe impact on the quality of life and survival rate of affected patients. Traditional tumor models have significant limitations in studying biological properties, tumor microenvironment, and treatment response, and the difficulty in obtaining HNSCC specimens has hampered our understanding and the development of treatment for the disease. Recent rapid development in bioprinting has provided new possibilities for tumor model construction, enabling precise control of cell arrangement and tissue structure to be more realistically simulated tumor biological properties. This review summarizes the latest progress of bioprinting in HNSCC tumor model construction, explores the application of different bioprinting technologies, the properties of constructed tumor models, and the potential applications of these models in drug screening and individualized treatment, aiming to provide reference and inspiration for future research and treatment of HNSCC.

Graphical abstract
Keywords
3D microenvironment
Bioprinting
Head and neck squamous cell carcinoma
Tumor model construction
Funding
This work was supported with grants from the National Natural Science Foundation of China, the Joint Fund of Hubei Provincial Health and Family Planning Commission (WJ2018H0110), and the National University of Singapore.
Conflict of interest
The authors declare no conflict of interest.
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International Journal of Bioprinting, Electronic ISSN: 2424-8002 Print ISSN: 2424-7723, Published by AccScience Publishing
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