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REVIEW

Designing methacrylic anhydride-based hydrogels for 3D bioprinting

Naisi Shen1 ,  Zhen Li1 ,  Pu Yang1 ,  Xiangjun Liu1 ,  Yikun Ju1 ,  Yue Hu1 ,  Bairong Fang1* ,  Liangle Liu2*
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1 Department of Plastic and Aesthetic (Burn) Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China
2 Department of Spinal Surgery, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, China
IJB, 4650 https://doi.org/10.36922/ijb.4650
Submitted: 24 August 2024 | Accepted: 14 October 2024 | Published: 15 October 2024
(This article belongs to the Special Issue New matrix materials for 3D Bioprinting)
© 2024 by the Author(s).. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Methacrylic anhydride (MA)-based hydrogels, derived by introducing methacryloyl groups to various polymer side chains, are promising bioinks for three-dimensional (3D) printing in medical applications. These hydrogels combine the inherent biocompatibility and therapeutic benefits of their parent polymers with the unique photocrosslinking properties conferred by the methacryloyl groups, allowing precise control over their mechanical properties through light-curing parameters. Using 3D biological compression, these hydrogels serve as bioinks for producing scaffolds with optimal porosity, facilitating cell adhesion, proliferation, and differentiation. This technology enables the precise spatial distribution of bioactive substances, offering targeted therapeutic treatment and controlled release. This review delved into recent advancements in bioprinting technologies, outlined the preparation of MA-based bioinks, and summarized factors influencing the resulting biological and mechanical properties of bioscaffolds. Additionally, the properties and applications of methylpropionic anhydride-based hydrogels in various medical fields were discussed, addressing current limitations and future challenges in integrating these hydrogels with 3D bioprinting for clinical applications.

Graphical abstract
Keywords
3D printing
3D-printed scaffold
Bioink
Light curing
Methacrylic anhydride-based compound
Funding
This work was supported by the Hunan Provincial Health Commission Scientific Research Project, China (C202304106744).
Conflict of interest
The authors declared no potential conflicts of interest with respect to the research, authorship, and publication of this article.
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International Journal of Bioprinting, Electronic ISSN: 2424-8002 Print ISSN: 2424-7723, Published by AccScience Publishing
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