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3D bioprinting technologies for the enhancement and application of functional lung organoid models

Jimin Jang1 ,  Jooyoung Lee2 ,  Sangryul Cha1 ,  Minkyoung Lee2 ,  Hyungseok Lee2,3* ,  Se-Ran Yang1*
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1 Department of Thoracic and Cardiovascular Surgery, School of Medicine, Kangwon National University, Chuncheon, Gangwon State, Republic of Korea
2 Department of Smart Health Science and Technology, College of Engineering Kangwon National University, Chuncheon, Gangwon State, Republic of Korea
3 Department of Mechanical and Biomedical, Mechatronics Engineering, College of Engineering, Kangwon National University, Chuncheon, Gangwon State, Republic of Korea
IJB, 4092 https://doi.org/10.36922/ijb.4092
Submitted: 30 June 2024 | Accepted: 14 August 2024 | Published: 16 August 2024
(This article belongs to the Special Issue The Latest Advancements in Bioprinting Technology)
© 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Respiratory diseases, ranging from minor infections to serious chronic diseases and malignancies, negatively affect the respiratory system and are influenced by various environmental factors such as air pollution, occupational hazards, and tobacco smoke, as well as lifestyle, genetic causes, and infectious agents. The prevalence and severity of respiratory diseases require the development of advanced models to better understand their pathophysiology and develop effective treatments. In this context, 3D bioprinting technology emerges as an innovative tool to create functional lung organoid models. The use of induced pluripotent stem cells and extracellular matrix in bioprinting enables the development of organoids that closely mimic human lung tissue. Bioprinting-based organoids can better replicate the dynamic environment of the human lung, facilitating more accurate disease modeling and drug testing. In this review, we highlight the potential of bioprinted lung organoids in understanding the mechanisms of chronic respiratory diseases, testing the efficacy and safety of new drugs, and exploring regenerative medicine approaches. The integration of advanced bioprinting and organoid technologies is a promising field in respiratory disease research and treatment, offering new hope for patients suffering from lung diseases.

 

Keywords
Alveolar organoid
Chronic respiratory disease
Bioprinting
Extracellular matrix
Induced pluripotent stem cells
Funding
This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (2020R1A5A8019180), the Ministry of Education (MOE) (2022RIS-005).
Conflict of interest
The authors declare they have no competing interests
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International Journal of Bioprinting, Electronic ISSN: 2424-8002 Print ISSN: 2424-7723, Published by AccScience Publishing
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