AccScience Publishing / IJB / Volume 9 / Issue 5 / DOI: 10.18063/ijb.757
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RESEARCH ARTICLE

Functional materials of 3D bioprinting for wound dressings and skin tissue engineering applications: A review

Huan Fang1,2† Jie Xu1,2† Hailin Ma1,2 Jiaqi Liu1 Erpai Xing1 Yuen Yee Cheng3 Hong Wang4 * Yi Nie2* Bo Pan5* Kedong Song1*
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1 State Key Laboratory of Fine Chemicals, Dalian R&D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024, Liaoning, China
2 Zhengzhou Institute of Emerging Industrial Technology, Zhengzhou 450000, Henan, China
3 Institute for Biomedical Materials and Devices, Faculty of Science, University of Technology Sydney, NSW 2007, Australia
4 Department of Orthopaedics, Dalian Municipal Central Hospital Affiliated of Dalian University of Technology, Dalian 116033, China
5 Department of Breast Surgery, The Second Hospital of Dalian Medical University, Dalian 116023, China
Submitted: 10 August 2022 | Accepted: 31 January 2023 | Published: 18 May 2023
© 2023 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

The skin plays an important role in vitamin D synthesis, humoral balance, temperature regulation, and waste excretion. Due to the complexity of the skin, fluids loss, bacterial infection, and other life-threatening secondary complications caused by skin defects often lead to the damage of skin functions. 3D bioprinting technology, as a customized and precise biomanufacturing platform, can manufacture dressings and tissue engineering scaffolds that accurately simulate tissue structure, which is more conducive to wound healing. In recent years, with the development of emerging technologies, an increasing number of 3D-bioprinted wound dressings and skin tissue engineering scaffolds with multiple functions, such as antibacterial, antiinflammatory, antioxidant, hemostatic, and antitumor properties, have significantly improved wound healing and skin treatment. In this article, we review the process of wound healing and summarize the classification of 3D bioprinting technology. Following this, we shift our focus on the functional materials for wound dressing and skin tissue engineering, and also highlight the research progress and development direction of 3D-bioprinted multifunctional wound healing materials.

Keywords
Functional materials
Wound healing
3D bioprinting
Dressing
Skin tissue engineering
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International Journal of Bioprinting, Electronic ISSN: 2424-8002 Print ISSN: 2424-7723, Published by AccScience Publishing