AccScience Publishing / IJB / Volume 9 / Issue 6 / DOI: 10.36922/ijb.0142
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REVIEW

Bioprinting technology for the management of diabetic foot disease: Emerging applications, challenges, and prospects

Fan Xu1 Shunli Rui1 Cheng Yang1 Xiaoyan Jiang1 Wei Wu2 Xianlun Tang3 David G. Armstrong4 Yu Ma1* Wuquan Deng1*
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1 Department of Endocrinology, School of Medicine, Chongqing Emergency Medical Center, Chongqing University Central Hospital, Chongqing 400014, China
2 Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing 400030, China
3 Chongqing Key Laboratory of Complex Systems and Bionic Control, College of Automation, Chongqing University of Posts and Telecommunications, Nan’an district, Chongqing 400065, China
4 Department of Surgery, Keck School of Medicine of University of Southern California, Los Angeles, CA 90033, USA
Submitted: 17 April 2023 | Accepted: 12 June 2023 | Published: 31 July 2023
(This article belongs to the Special Issue Bioprinting strategies for managing skin diseases and injuries)
© 2023 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

Most conventional therapies have limitations in the repair of complex wounds caused by chronic inflammation in patients with diabetic foot ulcers (DFUs). In response to the demand for more biotechnology strategies, bioprinting has been explored in the regeneration field in recent years. However, challenges remain regarding the structure of complex models and the selection of proper biomaterials. The purpose of this review is to introduce the current applications of bioprinting technology in chronic diabetic foot wound healing. First, the most common application of bioprinting in producing skin equivalents to promote wound healing is introduced; second, functional improvements in the treatment of chronic and difficult-to-heal DFU wounds facilitated by bioprinting applications are discussed; and last but not least, bioprinting applications in addressing unique diabetic foot disease characteristics are summarized. Furthermore, the present work summarizes material selection and correlations between three-dimensional (3D) bioprinting and a variety of biomimetic strategies for accelerating wound healing. Novel, biotechnological tools such as organoids for developing new biomaterials for bioprinting in the future are also discussed.

 

Keywords
Bioprinting
Wound; Skin
Diabetic foot disease
Biomaterial
Funding
This study was supported by the Joint Medical Key Research Programs of Chongqing Science and Technology Bureau and Health Commission Foundation (No. 2023ZDXM009), the Natural Science Foundation of Chongqing Municipal Science and Technology Bureau (No. CSTB2022NSCQMSX0489) awarded to Dr. Wuquan Deng and Dr. Shunli Rui, and the Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau, No. 2020FYYX241) awarded to Dr. Xiaoyan Jiang. This study is also partially supported by National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases (award number 1R01124789-01A1), and National Science Foundation (NSF) Center to Stream Healthcare in Place (#C2SHiP; CNS Award Number 2052578 awarded to Prof. David G. Armstrong).
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Conflict of interest
The authors declare no conflict of interest.
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International Journal of Bioprinting, Electronic ISSN: 2424-8002 Print ISSN: 2424-7723, Published by AccScience Publishing