Somatosensory amplification (SSA) is a cognitive-emotional construct defined as the tendency to perceive normal physiological sensations as unusually intense, disturbing, and threatening. Originally introduced by Barsky et al., SSA involves heightened attention to bodily sensations, catastrophic interpretations, and exaggerated emotional responses. This tendency is closely linked with various psychiatric disorders, including anxiety disorders, somatic symptom disorder, panic disorder, and health anxiety. SSA is also conceptually related to constructs such as interoception, somatization, and bodily awareness, although it remains distinct in its emphasis on cognitive-affective distortion. Neuroimaging studies suggest that SSA is associated with hyperactivation in brain regions responsible for somatic awareness and emotion regulation, such as the insula and anterior cingulate cortex. The SSA scale is the most commonly used tool to assess SSA, although complementary methods like heartbeat detection tasks and attentional bias paradigms are also employed. Therapeutically, cognitive-behavioral therapy, mindfulness-based interventions, and attention training programs have shown promise in reducing SSA levels. This review emphasizes the importance of SSA as a transdiagnostic mechanism that bridges bodily, emotional, and cognitive domains, with implications for both research and clinical practice. Future studies should further investigate SSA’s neurobiological basis and develop targeted interventions to address this amplifying tendency in diverse clinical populations.