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REVIEW

The endocannabinoid system: A new frontier in addressing psychosomatic challenges

Laura E. Torres-Mondragón1,2 ,  Luisa C. León-Pimentel1 ,  Daniel E. Pérez-Tamayo1 ,  Alberto K. De la Herrán Arita1*
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1 Department of Neurophysiology, Faculty of Medicine, Autonomous University of Sinaloa, Culiacán, México
2 Department of Molecular Biomedicine, Autonomous University of Sinaloa, Culiacán, México
JCBP 2024, 2(1), 2288 https://doi.org/10.36922/jcbp.2288
Submitted: 22 November 2023 | Accepted: 28 December 2023 | Published: 12 January 2024
© 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Psychosomatic disorders (PSD), alternatively referred to as psychophysiologic disorders, are characterized by hypothalamic-pituitary-adrenal (HPA) axis activation, posing a substantial challenge in clinical practice. These disorders constitute a collection of intricate medical conditions marked by the considerable impact of psychological and emotional factors on the onset, intensification, or persistence of physical symptoms. The endocannabinoid system, a complex regulatory network consisting of endocannabinoids, cannabinoid receptors, and associated enzymes, emerges as a key player in modulating the body’s stress response, emotional regulation, and immune function. This review delves into the bidirectional relationship between the endocannabinoid system and the HPA axis, elucidating the impact of endocannabinoid system modulation on stress responsiveness, immune modulation, and the intricate interplay between emotional well-being and physical symptoms. Through the synthesis of current scientific knowledge, this review aims to provide a comprehensive understanding of the role of the endocannabinoid system in PSD, offering insights that may pave the way for novel therapeutic approaches.

Keywords
Endocannabinoids
Hypothalamic-pituitary-adrenal axis
Immune system
Psychosomatic medicine
Psychophysiologic disorders
Funding
None.
Conflict of interest
The authors declare no conflicts of interest associated with the completion and submission of this review.
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Journal of Clinical and Basic Psychosomatics, Electronic ISSN: 2972-4414 Print ISSN: 3060-8562, Published by AccScience Publishing
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