AccScience Publishing / JCBP / Online First / DOI: 10.36922/jcbp.1040
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ORIGINAL RESEARCH ARTICLE

Correlations between depressive disorder, obstructive sleep apnea, and hypothalamic inflammation

Guanzhong Dong1† ,  Xuanyan Zhu1† ,  Qiaoyang Zhang1 ,  Yuwen Jiao2 ,  Yi Ma3 ,  Shumin Zhu1 ,  Lihao Zhang1 ,  Min Zhang4 ,  Liming Tang2* ,  Yin Cao1*
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1 Department of Psychology, The Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical University, Changzhou, 231000, China
2 Department of Gastrointestinal Surgery, The Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical University, Changzhou, 231000, China
3 Department of Radiology, The Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical University, Changzhou, 231000, China
4 Department of Neurology, The Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical University, Changzhou, 231000, China
JCBP 2024, 2(1), 1040 https://doi.org/10.36922/jcbp.1040
Submitted: 4 June 2023 | Accepted: 12 September 2023 | Published: 26 October 2023
© 2023 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Obesity is a significant public health concern in China, with a 2.5-fold increase in prevalence over the past 30 years. This increase corresponds to a rise in the prevalence of obstructive sleep apnea (OSA). This study aims to investigate the associations of OSA with depressive disorders and hypothalamic inflammation in obese young men. Between January 2020 and December 2021, 62 obese male patients were selected and divided into two groups: a depressive disorder group (18 cases) and a non-depressive disorder group (44 cases) according to the diagnostic criteria of the DSM-5 combined with depressive disorder. All patients were monitored using a portable sleep monitor. Hypothalamic inflammation was evaluated using quantitative magnetic resonance imaging (MRI) by calculating the signal intensity (SI) ratio of the T2-weighted phase of the hypothalamus/amygdala (H/A). Differences were observed in the respiratory event index (REI), lowest oxygen saturation, and oxygen desaturation index (P < 0.05). In the depressive disorder group, the left H/A was significantly higher than in the non-depressive disorder group (P = 0.002), whereas the right H/A did not differ significantly between the two groups (P > 0.05). Furthermore, the left H/A exhibited correlations with REI and body mass index (BMI) (P < 0.05), while no correlation was found between the right H/A and AHI (P > 0.05). In conclusion, our findings suggest that the left hypothalamic inflammation is positively correlated with the severity of OSA, implying that left hypothalamic inflammation may represent a potential mechanism underlying OSA in obese young patients with depressive disorders.

Keywords
Obesity
Hypothalamus inflammation
Depressive disorders
Obstructive sleep apnea
Funding
Changzhou Key Laboratory of Gastroenterology
Changzhou Science and Technology Program
Conflict of interest
All authors certify that they have no affiliations with or involvement in any organization or entity with any financial or non-financial interests in the subject matter or materials discussed in this manuscript.
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