Dear Colleagues,

Light-based three-dimensional (3D) printing has emerged as a transformative manufacturing paradigm in biomedical engineering, enabling the rapid, high-resolution fabrication of complex tissue-engineering scaffolds, cell-laden constructs, and functional biomimetic architectures through precise spatiotemporal control of photopolymerization processes. Technologies such as digital light processing (DLP), microstereolithography (μSLA), volumetric additive manufacturing (VAM), and two-photon polymerization (2PP) have unlocked unprecedented capabilities in constructing physiologically relevant microenvironments with intricate vascular networks, hierarchical porosity, and cellular heterogeneity. These advances are accelerating breakthroughs across a broad spectrum of biomedical applications, including organoid development, in vitro disease models, implantable medical devices, and in situ tissue repair.

This Special Issue aims to capture the state-of-the-art developments, critical challenges, and future directions in light-based 3D printing for biomedical applications. We seek to highlight how innovations in photochemistry, optical engineering, biomaterial design, and bioprinting strategies are converging to enable the fabrication of functional tissue constructs and clinically translatable solutions. The scope encompasses both the engineering of advanced light-based printing systems and their biological and preclinical validation.

The editors cordially invite submissions of original research articles, comprehensive reviews, and perspective papers focusing on (but not limited to) the following topics:

• Novel light-based 3D printing technologies and instrumentation, including but not limited to DLP, VAM, 2PP, and hybrid photo-fabrication systems;
• Photocurable biomaterial design and bio-ink development, encompassing photoinitiators, photopolymerizable hydrogels, and advanced resin formulations for cytocompatible and biodegradable constructs;
• High-resolution and high-speed bioprinting strategies, including multi-material printing, dynamic projection, and real-time process monitoring for enhanced fabrication fidelity;
• 3D-printed tissue-engineering scaffolds and cell-laden constructs, with emphasis on structural, mechanical, and biological characterization;
• Engineering of organoids, in vitro models, and organ-on-a-chip systems using light-based bioprinting approaches;
• In situ and in vivo light-based printing for minimally invasive tissue repair, wound healing, and personalized therapeutic interventions;
• Computational modeling, machine learning, and process optimization in light-driven additive manufacturing for biomedical applications.

We look forward to receiving your contributions.