Collagen is the most abundant structural protein in the extracellular matrix (ECM) of mammalian tissues and plays a pivotal role in regulating cell adhesion, proliferation, and differentiation. Owing to its intrinsic biocompatibility, biodegradability, and bioactivity, collagen has emerged as a key biomaterial in tissue engineering and regenerative medicine. In recent years, its use as a biomaterial ink in 3D bioprinting has gained increasing attention, enabling the fabrication of biomimetic constructs that closely recapitulate native tissue architecture.

This Special Issue, “Collagen-based bioinks for regenerative medicine applications,” aims to highlight recent advances in the design, optimization, and application of collagen-derived bioinks. Despite their potential, challenges such as poor mechanical properties, variability in source and extraction methods, and limited printability still hinder their widespread adoption. Contributions addressing novel crosslinking strategies, composite formulations, and advanced processing techniques are particularly encouraged.

A broad range of article types are welcome, including original research articles, review papers, and short communications, covering both fundamental and translational aspects of collagen-based bioinks in regenerative medicine.