AccScience Publishing / IJB / Online First / DOI: 10.36922/IJB026240248
Cite this article
1
Download
38
Views
Related Info Links
More by Authors Links
Journal Browser
Volume | Year
Issue
Search
News and Announcements
View All
REVIEW ARTICLE
Early Access

Clinical translation of 3D-bioprinted orthopedic grafts: Design specifications, evaluation domains, and regulatory considerations for bone, cartilage, and osteochondral repair

Yuan Chen1,2 Shuheng Yang3 Jiaqi Chen1 Minggan Guo1,2 Yahan Li1,2 Zhongyi Sun2* Fanchun Zeng2*
Show Less
1 School of Biomedical Engineering, Medical School, Shenzhen University, Shenzhen, Guangdong 518060, China
2 Central Laboratory, The Fifth People’s Hospital of Chongqing, Chongqing University, Chongqing 400044, China
3 Department of Urology, Dali Bai Autonomous Prefecture People’s Hospital (Yunnan West Central Hospital), Dali, Yunnan 671000, China
Received: 9 June 2026 | Revised: 12 July 2026 | Accepted: 21 July 2026 | Published online: 22 July 2026
© 2026 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

Three-dimensional (3D) bioprinting has advanced rapidly, but clinical translation of orthopedic grafts remains constrained by a mismatch between printable constructs and indication-specific failure modes. Bone, cartilage, and osteochondral defects impose distinct requirements: vascularized remodeling and load sharing for bone, phenotypic stability and low-friction durability for cartilage, and mechanically integrated compartmental organization for osteochondral repair. This narrative review synthesizes recent evidence on 3D bioprinted orthopedic grafts with a translational focus on design specifications, validation endpoints, manufacturing control, and regulatory readiness. Rather than treating bioinks, printing platforms, and cell sources as isolated technologies, the review organizes them according to clinical function: structural support, biological instruction, process control, maturation, immune compatibility, and product qualification. Current evidence indicates that many constructs remain validated mainly by early biological markers, representative imaging, or short-term animal outcomes, whereas clinically relevant tests of fatigue, wear, degradation-coupled mechanics, host-graft integration, vascular perfusion, immune response, sterility, dimensional tolerance, and release criteria are less consistently reported. Near-term translation appears most plausible for acellular or minimally cellular reinforced constructs, patient-specific but quality-testable bone scaffolds, and selected intraoperative applications with clear surgical utility. More complex living grafts that combine vascular, immune-instructive, and multi-tissue functions will require stronger preclinical models, standardized reporting, and product-specific regulatory strategies. Translation in orthopedic bioprinting should begin with the clinical failure mode and proceed toward measurable release specifications, not with printability alone.

Keywords
3D bioprinting
Orthopedic regeneration
Bone defect
Cartilage repair
Osteochondral interface
Vascularization
In situ bioprinting
Regulatory science
Share
Back to top
International Journal of Bioprinting, Electronic ISSN: 2424-8002 Print ISSN: 2424-7723, Published by AccScience Publishing