AccScience Publishing / IJB / Online First / DOI: 10.36922/ijb.4472
REVIEW
Early Access

3D bioprinting techniques and hydrogels for osteochondral integration regeneration

Haiwei Tang1 Enze Zhao1 Yahao Lai1 Anjin Chen1 Xiaoting Chen1 Weinan Zeng1 Xulin Hu2* Kai Zhou1* Zongke Zhou1*
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1 Department of Orthopedics and Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China
2 Clinical Medical College and Affiliated Hospital of Chengdu University, Chengdu, Sichuan Province, China
Submitted: 7 August 2024 | Accepted: 9 September 2024 | Published: 10 September 2024
© 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

Despite considerable advancements in regenerative medicine, restoring the osteochondral interface and facilitating the integration of osteochondral regeneration remains a significant clinical conundrum. This challenge is predominantly attributed to the scarcity of appropriate tissue engineering materials for replacing osteochondral defects and facilitating tissue regeneration. Three-dimensional (3D) bioprinting constitutes a promising approach for bone fabrication, as it not only allows for the design of precise personalized scaffolds but also encapsulates cells and growth factors, with the potential to replicate the functions of native tissues. Many critical properties of hydrogels, such as their mechanical properties, elasticity, and bioactivity, make them the most prevalently utilized bioinks in tissue engineering. In addition, their structure can be easily adjusted to meet the needs of different situations. Therefore, 3D-bioprinted hydrogel scaffolds may have promising prospects for integrated osteochondral repair and are receiving increasing attention. In this review, we describe the current problems encountered in the field of osteochondral integration repair and review the latest advances in current 3D printing technology and 3D bioprinting hydrogel scaffolds. We propose prospects for the development of novel 3D-bioprinted hydrogel scaffolds, providing cues for future research directions.

Keywords
Osteochondral integration repair
3D-bioprinted
Hydrogels
Funding
Financial support and sponsorship: The authors would like to thank the following funding sources: The National Natural Science Foundation of China (82002304, 82172394, U22A20280), 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University (2023HXFH012) and 1.3.5 project for disciplines of excellence, West China Hospital, University (ZYGD23033).
Conflict of interest
The authors declare no competing interest.
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International Journal of Bioprinting, Electronic ISSN: 2424-8002 Print ISSN: 2424-7723, Published by AccScience Publishing