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Advancements in 3D bioprinting for precision medicine: Enhancing patient-derived organoids and extracellular vesicle applications in inflammatory diseases

Hyun Sung Park1 ,  Jae Han Park1 ,  Mi-Kyung Oh1* ,  Kyung-Rok Yu1*
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1 Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Science, Seoul National University, Seoul, Republic of Korea
IJB 2024, 10(5), 4054 https://doi.org/10.36922/ijb.4054
Submitted: 27 June 2024 | Accepted: 25 July 2024 | Published: 30 July 2024
(This article belongs to the Special Issue The Latest Advancements in Bioprinting Technology)
© 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

The integration of three-dimensional (3D) bioprinting with cultures of patient-derived organoids represents a transformative advancement in precision medicine, enabling the creation of anatomically accurate and physiologically relevant tissue models. These models are pivotal for personalized disease modeling, therapeutic development, and regenerative medicine. 3D bioprinting enhances the structural and functional fidelity of organoids, thereby improving their application in drug screening and disease intervention strategies. Additionally, this technology facilitates the study of extracellular vesicles (EVs) released from patient-derived organoids, which are rich in bioactive molecules and play crucial roles in modulating immune responses. Particularly in chronic inflammatory conditions, these organoid-derived EVs are instrumental in cellular communication and improve our understanding of disease mechanisms beyond traditional biopsies. This review focuses on the latest developments in 3D bioprinting techniques for organoids and EVs, highlighting their potential to revolutionize the treatment of inflammatory diseases through precision medicine.  

Keywords
3D bioprinting
Patient-derived organoids
Extracellular vesicles
Immune-mediated chronic diseases
Personalized medicine
Funding
This work was supported by the National Research Foundation of Korea (NRF) funded by the Republic of Korea government (2022R1C1C1009606), and the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education (2022R1I1A1A01071265).
Conflict of interest
The authors declare they have no competing interests
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International Journal of Bioprinting, Electronic ISSN: 2424-8002 Print ISSN: 2424-7723, Published by AccScience Publishing
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