AccScience Publishing / IJB / Online First / DOI: 10.36922/ijb.2516
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RESEARCH ARTICLE

Personalized light-curable polyurethane palatal prosthesis designed and fabricated based on computer fluid dynamics and 3D printing to repair palatal fistula

Qiwei Chen1 ,  Haihuan Gong2 ,  Yilin Wang1 ,  Yanyan Zhao3 ,  Hong Zhao4 ,  Zhiwei Lin5 ,  Jingya Yang6,7 ,  Manoj Kumar Vashisth1 ,  Lixiang Zhao8 ,  Yunlu Dai9* ,  Wenhua Huang1,4,6*
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1 Department of Anatomy, Guangdong Provincial Key Laboratory of Medical Biomechanics, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China
2 Department of Periodontics, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou, Guangdong, China
3 Department of Science and Education, The Second Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan, China
4 Department of Nursing and Health, Huizhou Economics and Polytechnic College, Huizhou, Guangdong, China
5 School of Basic Medical Sciences, Guangdong Medical University, Dongguan, Guangdong, China
6 Department of Otolaryngology - Head and Neck Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, China
7 School of Basic Medical Sciences, Guangxi Medical University, Nanning, Guangxi, China
8 Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guangxi Medical University, Nanning, Guangxi, China
9 Faculty of Health Sciences and MoE Frontiers Science Center for Precision Oncology, University of Macau, Macau, China
IJB, 2516 https://doi.org/10.36922/ijb.2516
Submitted: 23 December 2023 | Accepted: 15 February 2024 | Published: 19 March 2024
© 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Cleft palate surgery most commonly results in palatal fistula, but this complication can also be observed in congenital malformations, palatal tumors, and autoimmune diseases. Palatal fistula repair is crucial in restoring everyday speech and swallowing function, improving patients’ psychological and social well-being. However, treating palatal fistula remains challenging for oral and maxillofacial surgeons. In addition, fabricating a palatal fistula prosthesis with a precise fit to the fistula using traditional techniques is hardly achievable in the design and production process. In recent years, digital technology has been increasingly applied in palatal fistula prosthesis fabrication. Based on computer fluid dynamics (CFD)-assisted design and three-dimensional printing technology, we developed a personalized palatal prosthesis made of light-cured polyurethane to repair palatal fistula and restore normal airflow during speech. Material property tests show that this light-cured polyurethane material has excellent hydrophilicity, mechanical properties, water resistance, and good rheological performance. The excellent biocompatibility of the polyurethane palatal prosthesis was confirmed in in vivo and in vitro experiments. The study results also indicate that CFD pre-analysis provides accurate guidance for palatal fistula design and future evaluation of outcomes. Therefore, CFD pre-analysis and additive manufacturing synergy provide a new treatment method. In combination with the excellent biocompatibility and mechanical properties of polyurethane, this study proposes a new strategy for treating refractory palatal fistula and extensive palatal defects, aiming to reduce the difficulty of prosthesis fabrication and maximize the restoration effect and quality of life for patients.

 

Keywords
Prosthesis
3D printing
Computer fluid dynamics
Polyurethane
Photocuring
Funding
This work was financially supported by the National Key R&D Program of China (Grant no. 2022YFB4600600), the National Natural Science Foundation of China (Grant no. 31972915 and no. 32271181), the Guangdong Basic and Applied Basic Research Foundation (Grant no. 2020B1515120001), and the Guangzhou Science and Technology Plan—Municipal School Joint Funding Basic and Applied Research Project (No. 202201020156).
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Conflict of interest
The authors declare no conflicts of interest.
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International Journal of Bioprinting, Electronic ISSN: 2424-8002 Print ISSN: 2424-7723, Published by AccScience Publishing
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