AccScience Publishing / IJB / Volume 10 / Issue 1 / DOI: 10.36922/ijb.1285
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RESEARCH ARTICLE

Improving the transdermal delivery of vitamin C by 3D-printed microneedle particles for alleviating skin photodamage

Li Zhang1† ,  Haofan Liu1† ,  Linghong Guo2,3,4† ,  Xuebing Jiang1 ,  Siyi Wang1,5 ,  Run Tian1,2 ,  Yiting Huang1 ,  Xian Jiang2,3* ,  Maling Gou1*
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1 State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, 610041 Chengdu, China
2 Department of Dermatology, West China Hospital, Sichuan University, 610041 Chengdu, China
3 Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, 610041 Chengdu, China
4 Tianfu Jincheng Laboratory & Institute of Future Medical Innovation, City of Future Medicine, 641400 Chengdu, China
5 Huahang Microcreate Technology Co., Ltd, 610042 Chengdu, China
IJB 2024, 10(1), 1285 https://doi.org/10.36922/ijb.1285
Submitted: 11 July 2023 | Accepted: 15 August 2023 | Published: 8 January 2024
© 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Skin photodamage is a common disease that can cause various skin problems, and vitamin C is frequently used as an antioxidant to protect the skin from photodamage. However, vitamin C is a charged and hydrophilic molecule, which decreases skin permeability. In this study, we developed a type of microneedle particles (MNPs) to enhance topical vitamin C delivery. The MNPs are millimeter-sized particles with micron-sized needle-like structures that can be rapidly and accurately fabricated through a digital light processing (DLP)-based micro-printing process. The mechanical properties of these MNPs are reliable for forming micropores across the stratum corneum in a painless manner. Following a topical application to the dorsal skin of mice, the MNPs increased the permeability of medications. The effectiveness of vitamin C in mitigating skin photodamage is significantly improved. In conclusion, this study presents micro-printing of MNPs for transdermal vitamin C delivery, which has potential applications in future treatment of skin photodamage.

Keywords
Microneedle particles
Micro-printing
Vitamin C delivery
Skin photodamage
Funding
This work was supported by National Key Research and Development Program of China (2021YFF1200800), Sichuan Science and Technology Program (2021JDTD0001, 2022YFQ0004), Fundamental Research Funds for the Central Universities (2022SCU12046), and National Natural Science Foundation of China (82073473).
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Conflict of interest
The authors declare no conflicts of interest.
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International Journal of Bioprinting, Electronic ISSN: 2424-8002 Print ISSN: 2424-7723, Published by AccScience Publishing
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