AccScience Publishing / IJAMD / Online First / DOI: 10.36922/ijamd.2420

Manufacturing multi-organs database: A comprehensive, predictive, and analytical biofabrication database

Jingmin An1,2† Wenjuan Cui3,4† Haolin Chen1,2,4† Juan Wu1,2,4 Yishuang Liang3,4 Na Li3 Yi Du3,4* Shuyu Zhang1,2* Qi Gu1,2,4*
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1 Key Laboratory of Organ Regeneration and Reconstruction, Institute of Zoology, Chinese Academy of Sciences, Chaoyang District, Beijing, China
2 Beijing Institute for Stem Cell and Regenerative Medicine, Chaoyang District, Beijing, China
3 Computer Network Information Center, Chinese Academy of Sciences, Haidian District, Beijing, China
4 University of Chinese Academy of Sciences, Huairou District, Beijing, China
IJAMD 2024, 1(1), 75–87;
Submitted: 12 December 2023 | Accepted: 8 January 2024 | Published: 29 January 2024
© 2024 by the Author(s0. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( )

Biofabrication, broadly described as “a process that results in a defined product with biological function,” has undergone a revolution in recent years. This revolution has led to an explosion of literature containing valuable data and insights on bioactive materials and machine learning-aided design. However, the accessibility and comprehension of this rich data source remain a challenge, necessitating the creation of a comprehensive database. Herein, we present the manufacturing multi-organs database (MMDB), a real-time updating database developed to foster an all-inclusive understanding of biofabrication by leveraging machine learning for standardized analysis of material properties and manufacturing processes. The MMDB aids in identifying commonly used cells, materials, and culture strategies in biofabrication by analyzing over 5000 papers related to 37 human organs. Leveraging machine learning models, it predicts optimal printing parameters and organ functionality metrics, thereby streamlining experimental designs and reducing costs. In addition, MMDB offers knowledge services that encompass hotspot analysis, trend identification, international collaboration analysis, and comprehensive knowledge maps of organ functions and biomaterials. We believe that the MMDB, serving as a crucial and readily accessible knowledge base, will fundamentally facilitate the design and optimization of biofabrication experiments. Moreover, by accelerating the discovery of optimal parameters, the MMDB has the potential to offer invaluable insights into organ function, propelling the field of biofabrication toward more efficient and effective organ manufacturing.

Organ function
Strategic Priority Research Program of the Chinese Academy of Sciences
National Natural Science Foundation of China
CAS Project for Young Scientists in Basic Research
CAS Pioneer Hundred Talents Program
CAS Engineering Laboratory for Intelligent Organ Manufacturing
Incubation Foundation of Beijing Institute for Stem Cell and Regenerative Medicine
China Postdoctoral Science Foundation
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Conflict of interest
The authors declare that they have no competing interests.
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International Journal of AI for Materials and Design, Electronic ISSN: 3029-2573 Published by AccScience Publishing