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ORIGINAL RESEARCH ARTICLE

Morphological signs of neurodegenerative and inflammatory processes in the brain of rats on a high-calorie diet

Tatyana E. Kuznetsova1 ,  Tatyana A. Mityukova1* ,  Anastasia A. Basalai1 ,  Olga Y. Poluliakh1
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1 Department of Laboratory of Biomedical Technologies and Medical Rehabilitation, Institute of Physiology, National Academy of Sciences of Belarus, Minsk, Republic of Belarus
Global Translational Medicine, 5000 https://doi.org/10.36922/gtm.5000
Submitted: 30 September 2024 | Revised: 30 December 2024 | Accepted: 2 January 2025 | Published: 21 January 2025
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

Much attention has been focused on studying the effects of obesity, particularly on the central nervous system (CNS). This study investigated the histoarchitecture of the prefrontal cortex (PFC) and hippocampus as well as the behavioral characteristics in male and female Wistar rats with diet-induced visceral obesity. The influence of a high-calorie diet on male and female rats reveals sex-specific changes in glial cells and the peculiarities of neurodegenerative processes in the PFC and hippocampal regions. In the context of visceral obesity, signs of depression were observed in male rats, whereas female rats showed no such signs. These results confirm the sex-specific effect of visceral obesity on the CNS.

Keywords
High-calorie diet
Visceral obesity
Rats
Prefrontal cortex
Hippocampus
Signs of inflammation and neurodegeneration
Funding
The work was supported by the State Program for Scientific Research (No.:4.1.1.5) of the National Academy of Sciences of Belarus.
Conflict of interest
The authors declare that they have no competing interests.
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Global Translational Medicine, Electronic ISSN: 2811-0021 Print ISSN: 3060-8600, Published by AccScience Publishing
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