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REVIEW ARTICLE

 Advancements in cardiac regenerative therapy: Scalable human iPSC-derived cardiomyocyte differentiation and maturation

Tadahisa Sugiura1†* ,  Dhienda C. Shahannaz1† ,  Brandon E. Ferrell1 ,  Taizo Yoshida2
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1 Department of Cardiothoracic and Vascular Surgery, Montefiore Medical Center/Albert Einstein College of Medicine, New York, United States of America
2 Department of Surgery, Montefiore Medical Center/Albert Einstein College of Medicine, New York, United States of America
Global Translational Medicine, 5745 https://doi.org/10.36922/gtm.5745
Submitted: 1 November 2024 | Accepted: 27 November 2024 | Published: 8 January 2025
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
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Abstract

The demand for mass production of induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) is escalating, driven by their potential to revolutionize cardiac regenerative therapies. The development of large-scale production protocols for iPSC-CMs is crucial to attain their therapeutic potential, enabling the treatment of millions of patients’ worldwide suffering from cardiovascular diseases. However, the scalable production of iPSC-CMs hinges on overcoming several critical challenges, including cellular differentiation and maturation. In pursue of tackling these challenges, researchers are investigating novel strategies such as prolonged culture periods, mechanical stimulation, and co-culture with supporting cell types. Overcoming these challenges is essential for unlocking the full potential of iPSC-CMs and paving the way for a new era in cardiac regenerative medicine. In this review, following topics are covered: (1) improvement of differentiation and maturation of iPSC-CMs and (2) scalable production of iPSC-CMs.

Keywords
Induced pluripotent stem cell
Cardiac regenerative therapy
Cardiomyocyte
Stem cell maturation
Clinical translation
Funding
None.
Conflict of interest
Tadahisa Sugiura is the Editorial Board Member of this journal and Guest Editor of this special issue, but was not in any way involved in the editorial and peer-review process conducted for this paper, directly or indirectly. Separately, other authors declared that they have no known competing financial interests or personal relationships that could have influenced the work reported in this paper.
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Global Translational Medicine, Electronic ISSN: 2811-0021 Print ISSN: 3060-8600, Published by AccScience Publishing
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