AccScience Publishing / GTM / Volume 2 / Issue 1 / DOI: 10.36922/gtm.v2i1.229
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REVIEW

The multifaceted functions of mineralocorticoid receptor in cardiometabolic disease

Jian-Yong Sun1,2 Yong-Li Wang2 Hong Zhu1,2 Sheng-Zhong Duan1,2*
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1 Laboratory of Oral Microbiota and Systemic Diseases, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China
2 National Centre for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology, Shanghai 200011, China
3 Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China
Global Translational Medicine 2023 , 2(1), 229; https://doi.org/10.36922/gtm.v2i1.229
Submitted: 19 October 2022 | Accepted: 24 November 2022 | Published: 12 January 2023
© 2023 by the Author(s). Licensee AccScience Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

Cardiometabolic diseases (CMDs), which cause 31% of all global deaths, are one of the greatest public health challenges. Mineralocorticoid receptor (MR), as a key nuclear transcription factor, is an important drug target for the treatment of CMDs. It is known that MR is expressed in almost all tissues and organs involved in cardiovascular homeostasis, including immune tissue, adipose tissue, brain, heart, kidney, and blood vessels. In the pathophysiology of CMDs, MR exerts different functions in different tissues and cells. This review summarizes the roles of MR in various cell types and discusses the molecular mechanisms through which MR exerts it functions in CMDs.

Keywords
Cardiometabolic diseases
Mineralocorticoid receptor
Mineralocorticoid receptor antagonist
Funding
National Natural Science Foundation of China
Innovative Research Team of High-Level Local Universities in Shanghai
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Conflict of interest
The authors declare that they have no competing interest.
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Global Translational Medicine, Electronic ISSN: 2811-0021, Print ISSN: TBA, Published by AccScience Publishing