AccScience Publishing / GTM / Volume 2 / Issue 1 / DOI: 10.36922/gtm.v2i1.218
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The vasculoprotective effects of resveratrol are mediated via Kruppel-like factor 2 dependent protection of endothelial barrier function

Xianming Zhou1,2† Lily Lin4† Hong Shi1,3,4*
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1 Case Cardiovascular Research Institute, Case Western Reserve University School of Medicine, Cleveland, OH, USA
2 Department of Cardiovascular Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
3 Division of Rheumatology, Medical College of Georgia at Augusta University, Augusta, GA, USA
4 Vascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA
Global Translational Medicine 2023, 2(1), 218
Submitted: 11 October 2022 | Accepted: 24 November 2022 | Published: 10 January 2023
© 2023 by the Author(s). Licensee AccScience Publishing, Singapore. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( )

Resveratrol is a naturally occurring polyphenolic compound that is thought to have vasculoprotective properties. Its observed effects are proposed, in part, to be mediated through the induction of endothelial Krϋppel-like factor 2 (KLF2) expression. KLF2 is a nuclear transcription factor that is highly expressed within the vascular endothelium. Studies from our laboratory and others have shown that this protein mediates vascular function through its transactivation domain, and its targeted expression promotes vascular health, notably by acting as an important positive regulator of endothelial barrier function. In this study, we demonstrate that resveratrol possesses endothelial barrier protective effects dependent on the presence of KLF2, with several key endothelial tight junction proteins expressed in a KLF2-dependent manner. Collectively, our findings identify KLF2 as essential for resveratrol-mediated endothelial barrier protection, thus further implicating KLF2 as a critical vasculoprotective factor.

Krϋppel-like factor 2
Barrier function

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Conflict of interest
The authors have declared that no conflicts of interest exist.
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Global Translational Medicine, Electronic ISSN: 2811-0021 Print ISSN: TBA, Published by AccScience Publishing