AccScience Publishing / GHES / Online First / DOI: 10.36922/ghes.8547
REVIEW ARTICLE

A comprehensive review of semaglutide in treating Type 2 diabetes and obesity

Isidoros Mentis1* Evangelia Tzeravini2 Nikolaos Tentolouris2
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1 Research Unit and Diabetes Center, 2nd Department of Internal Medicine, Attikon University Hospital, Medical School of the National and Kapodistrian University of Athens, Athens, Greece
2 Diabetes Center, First Department of Propaedeutic Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, Athens, Greece
Submitted: 15 January 2025 | Revised: 28 February 2025 | Accepted: 5 March 2025 | Published: 19 March 2025
© 2025 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

Type 2 diabetes (T2D) and obesity are closely interlinked metabolic disorders contributing significantly to global health challenges and economic burdens. Effective treatment strategies are crucial for improving patient outcomes and reducing healthcare costs. This review was conducted by selecting published articles that evaluate therapeutic options for individuals with T2D and obesity. A bibliographic search was performed, with a focus on the effectiveness and financial viability of semaglutide compared to other antidiabetic treatments. Obesity is a major risk factor for T2D. Global healthcare costs for T2D management are expected to reach $1.05 trillion by 2045, with obesity-related complications further escalating the economic burdens. The financial impacts of obesity-related comorbidities have been extensively documented. It has been demonstrated that a 5 – 10% weight loss can improve metabolic outcomes and reduce healthcare expenditures. Semaglutide, a glucagon-like peptide-1 receptor agonist, has demonstrated superior efficacy in weight reduction and glycemic control compared to other treatments. This medication also significantly reduced waist circumference and cardiovascular risks while improving lipid profiles. Cost-effectiveness analyses suggest that semaglutide offers long-term financial benefits by reducing T2D-related complications and hospitalizations. The evaluations by the Health Technology Assessment on semaglutide lend credence for including this medication in the national healthcare policies due to its potential to improve public health outcomes and aid in ensuring financial sustainability in healthcare systems. Semaglutide emerges as a highly effective therapeutic option for patients with T2D and obesity, providing both clinical and economic benefits. In summary, prioritizing access to effective weight management treatments like semaglutide can mitigate obesity-related complications, enhance quality of life, and generate substantial cost savings for healthcare providers worldwide.

Keywords
Type 2 diabetes
Obesity
Semaglutide
Healthcare systems
Health technology assessment
Funding
None.
Conflict of interest
The authors declare that there are no competing interests.
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