AccScience Publishing / GHES / Online First / DOI: 10.36922/ghes.2876
PERSPECTIVE ARTICLE

Multidrug-resistant tuberculosis: Successes, challenges, and the road ahead

Dominic Worku1,2*
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1 Morriston Hospital, Swansea Bay University Health Board, Swansea, United Kingdom
2 Public Health Wales, Cardiff, United Kingdom
Submitted: 4 February 2024 | Accepted: 7 April 2024 | Published: 20 May 2024
© 2024 by the Author(s). This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution 4.0 International License ( https://creativecommons.org/licenses/by/4.0/ )
Abstract

Tuberculosis (TB) is a leading cause of infection-related mortality globally and imposes a significant burden on morbidity among survivors. While progress has been achieved toward the World Health Organization’s End TB goal, it has been slower than anticipated and, in part, reversed by the impact of the severe acute respiratory syndrome coronavirus 2 pandemic. Multidrug-resistant TB (MDR-TB) presents a formidable challenge, characterized by catastrophic costs, reduced treatment success rates, and increased loss to follow-up, leading to its perpetuation in local communities and the risk of onward transmission. Given this, the need to reshape services and refine management in a cost-effective manner is of paramount importance, particularly in developing countries where the majority of cases reside. In this short piece, we discuss the economic impact of MDR-TB and how this impact can be mitigated through several methods, including decentralized models of care.

Keywords
Multidrug-resistant tuberculosis
Tuberculosis
End TB
Economics
Management
Funding
None.
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Conflict of interest
The author declares having no competing interests.
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